Ribonucleotide Reductase

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers.

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Background

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Gene Data

Ribonucleotide Reductase Inhibitors
Cat. No.	产品名称/活性
5962	3-AP
	Ribonucleotide reductase inhibitor; also an iron chelator
5292	Cladribine
	Ribonuclease reductase inhibitor; deoxyadenosine analog
3259	Gemcitabine hydrochloride
	Ribonucleotide reductase inhibitor

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.

RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.

External sources of pharmacological information for Ribonucleotide Reductase :

BJP Guide

Literature for Ribonucleotide Reductase

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