3-AP

Cat. No. 5962 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ribonucleotide reductase inhibitor; also an iron chelator

别名： 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

化学名： 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 3-AP

3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

技术数据 for 3-AP

分子量	195.24
公式	C₇H₉N₅S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	143621-35-6
PubChem ID	9571836
InChI Key	XMYKNCNAZKMVQN-NYYWCZLTSA-N
Smiles	NC(N/N=C/C1=C(C=CC=N1)N)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 3-AP

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	19.52	100

制备储备液 for 3-AP

以下数据基于产品分子量 195.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.61 mL	51.22 mL
5 mM	1.02 mL	5.12 mL	10.24 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.1 mL	0.51 mL	1.02 mL

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产品说明书 for 3-AP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 3-AP

参考文献是支持产品生物活性的出版物。

Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204 PMID: 24486217

Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3 PMID: 10470363

Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672 PMID: 1433178

If you know of a relevant reference for 3-AP, please let us know.

按标靶查看相关产品

关键词: 3-AP, 3-AP supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, 3-aminopyridine-2-carboxaldehyde, thiosemicarbazone, Reductase, DNA,, RNA, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 5962, Tocris Bioscience

1 篇 3-AP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 3-AP 的部分引用包括：

Chitambar et al (2013) Iron-targeting antitumor activity of gal. compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956 PMID: 22900955

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