AZ1 USP25/28 inhibitor

Cat. No. 7845 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective USP25 and USP28 inhibitor

化学名： 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AZ1 USP25/28 inhibitor

AZ1 USP25/28 inhibitor is a selective inhibitor of USP28 (IC₅₀ = 0.6 μM, K_d= 0.2 - 3.7 μM) and USP25 (IC₅₀ = 0.7 μM). AZ1 USP25/28 inhibitor exhibits selectivity for USP25 and USP28 over other DUB family members. The compound dose-dependently reduces c-Myc levels in colon carcinoma cells in vitro and induces cell death (EC₅₀ values are 18 - 20 μM). In a mouse Alzheimer's disease model, AZ1 USP25/28 inhibitor reduces amyloid burden, attenuates microglial activation and improves synaptic and cognitive function.

技术数据 for AZ1 USP25/28 inhibitor

分子量	422.21
公式	C₁₇H₁₆BrF₄NO₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2165322-94-9
PubChem ID	135397656
InChI Key	ITHSFXDGKQYOED-UHFFFAOYSA-N
Smiles	FC1=CC=C(COC2=CC=C(C=C2CNCCO)Br)C=C1C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ1 USP25/28 inhibitor

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	42.22	100

制备储备液 for AZ1 USP25/28 inhibitor

以下数据基于产品分子量 422.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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产品说明书 for AZ1 USP25/28 inhibitor

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AZ1 USP25/28 inhibitor

参考文献是支持产品生物活性的出版物。

Wrigley et al (2017) Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily. ACS Chem.Biol. 12 3113 PMID: 29131570

Zheng et al (2021) Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25. Sci.Adv. 7 eabe1340 PMID: 33523861

Zheng et al (2022) USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation. J.Clin.Invest. 132 e152170 PMID: 35229730

If you know of a relevant reference for AZ1 USP25/28 inhibitor, please let us know.

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