BCI

Cat. No. 7481 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： DUSP6 and DUSP1 inhibitor

化学名： 3-(Cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1H-inden-1-one

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BCI

BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC₅₀ values are 8.0 μM and 13.3 μM respectively). Increases P2X₇ receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.

技术数据 for BCI

分子量	317.42
公式	C₂₂H₂₃NO
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	15982-84-0
PubChem ID	6419844
InChI Key	XJDKPLZUXCIMIS-HMMYKYKNSA-N
Smiles	O=C1/C(C(C2=C1C=CC=C2)NC3CCCCC3)=C/C4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BCI

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	31.74	100
	ethanol	15.87	50

制备储备液 for BCI

以下数据基于产品分子量 317.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.5 mL
5 mM	0.63 mL	3.15 mL	6.3 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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产品说明书 for BCI

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BCI

参考文献是支持产品生物活性的出版物。

Zhang et al (2023) A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction. Dis.Model.Mech. 16 dmm049662 PMID: 36478044

Shin et al (2018) BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. Sci.China Life Sci. 61 1243 PMID: 29524123

Benito-León et al (2022) BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells. Front.Cell Dev.Biol. 15 1049566 PMID: 36589747

Unni et al (2018) Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. eLife 7 e33718 PMID: 30475204

If you know of a relevant reference for BCI, please let us know.

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关键词: BCI, BCI supplier, dual, specificity, phosphatase, DUSP1, DUSP6, P2X7, receptor, neuroblastoma, EGFR, KRAS, lung, cancer, NSCLC, apoptosis, FGF, signaling, myocardial, progenitor, macrophage, anti-inflammatory, heart, MI, infarction, p53, allosteric, inhibitors, inhibits, Protein, Tyrosine, Phosphatases, Other, MAPK, 7481, Tocris Bioscience

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