cAMPS-Sp, triethylammonium salt

Cat. No. 1333 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Cell-permeable cAMP analog

化学名： (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for cAMPS-Sp, triethylammonium salt

cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

R-enantiomer also available.

技术数据 for cAMPS-Sp, triethylammonium salt

分子量	446.46
公式	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	93602-66-5
PubChem ID	57369926
InChI Key	OXIPZMKSNMRTIV-UHFFFAOYSA-N
Smiles	[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for cAMPS-Sp, triethylammonium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	44.65	100

制备储备液 for cAMPS-Sp, triethylammonium salt

以下数据基于产品分子量 446.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.2 mL	22.4 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for cAMPS-Sp, triethylammonium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for cAMPS-Sp, triethylammonium salt

参考文献是支持产品生物活性的出版物。

Dostmann et al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484 PMID: 2162349

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

Lin et al (2006) Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 51 747 PMID: 16806304

O'Brian et al (1982) A kinetic study of interactions of (R_p)- and (S_p)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 21 4371 PMID: 6289880

If you know of a relevant reference for cAMPS-Sp, triethylammonium salt, please let us know.

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关键词: cAMPS-Sp, triethylammonium salt, cAMPS-Sp, triethylammonium salt supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Protein, Kinase, A, 1333, Tocris Bioscience

2 篇 cAMPS-Sp, triethylammonium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 cAMPS-Sp, triethylammonium salt 的部分引用包括：

Keng et al (2012) Dual regulation by ethanol of the inhibitory effects of KA on spinal NMDA-induced pressor responses in rats. J Biomed Sci 19 11 PMID: 22300389

Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221

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