Carvedilol

Cat. No. 2685 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and non-selective β antagonist; also potent α₁ antagonist

别名： BM 14190

化学名： 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Carvedilol

Carvedilol is a potent β-adrenoceptor and α₁-adrenoceptor antagonist (K_i values are 0.81, 0.96 and 2.2 nM for β₁-, β₂- and α₁-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K⁺ (K_IR) channels, voltage-dependent Ca²⁺ channels and exhibits antioxidant properties at higher concentrations.

化合物库 for Carvedilol

Carvedilol is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Carvedilol

分子量	406.47
公式	C₂₄H₂₆N₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	72956-09-3
PubChem ID	2585
InChI Key	OGHNVEJMJSYVRP-UHFFFAOYSA-N
Smiles	COC1=C(OCCNCC(O)COC2=CC=CC3=C2C2=C(N3)C=CC=C2)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Carvedilol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.64	100
	ethanol	20.32	50

制备储备液 for Carvedilol

以下数据基于产品分子量 406.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for Carvedilol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Carvedilol

参考文献是支持产品生物活性的出版物。

Ponicke et al (2002) Differential effects of bucindolol and carve. on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71 PMID: 11907159

Kikuta et al (2006) Carvedilol blocks cardiac K_ATP and K_G but not I_K1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529 47 PMID: 16325804

Ohlstein et al (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 90 6189 PMID: 8327499

If you know of a relevant reference for Carvedilol, please let us know.

按标靶查看相关产品

关键词: Carvedilol, Carvedilol supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, β-adrenergic, beta-adrenergic, b-adrenergic, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, Non-Selective, Adrenoceptors, BM14190, BM, 14190, Non-selective, Adrenergic, Beta, Receptors, Alpha-1, 2685, Tocris Bioscience

3 篇 Carvedilol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Carvedilol 的部分引用包括：

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315

Ajmo et al (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Nat Commun 218 47 PMID: 19371742

Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319

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