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CGS 9343B

Cat. No. 2255 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Calmodulin antagonist
别名： Zaldaride maleate
化学名： 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGS 9343B

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.

技术数据 for CGS 9343B

分子量 544.61
公式 C26H28N4O2.C4H4O4
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 109826-27-9
PubChem ID 6450522
InChI Key NGODOSILXOFQPH-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGS 9343B

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.23 50
ethanol 5.45 10 温和加热

制备储备液 for CGS 9343B

以下数据基于产品分子量 544.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.67 mL 18.36 mL 36.72 mL
2.5 mM 0.73 mL 3.67 mL 7.34 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
25 mM 0.07 mL 0.37 mL 0.73 mL

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产品说明书 for CGS 9343B

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for CGS 9343B

参考文献是支持产品生物活性的出版物。

Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535 PMID: 3033469

Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183 PMID: 1379190

Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195 PMID: 12419798

If you know of a relevant reference for CGS 9343B, please let us know.

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关键词: CGS 9343B, CGS 9343B supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Zaldaride, maleate, 2255, Tocris Bioscience

2 篇 CGS 9343B 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGS 9343B 的部分引用包括：

Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Eur J Immunol 13 e1002233 PMID: 26334624

Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434

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