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CS 640

Cat. No. 7982 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent CaM kinase I inhibitor
化学名： 2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CS 640

CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC50 values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.

技术数据 for CS 640

分子量 397.53
公式 C21H31N7O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2388506-83-8
PubChem ID 145946080
InChI Key BWBUPDTUXQDHSX-AWEZNQCLSA-N
Smiles NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CS 640

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.95 20
ethanol 3.98 10

制备储备液 for CS 640

以下数据基于产品分子量 397.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.58 mL 62.89 mL 125.78 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
2 mM 1.26 mL 6.29 mL 12.58 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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参考文献 for CS 640

参考文献是支持产品生物活性的出版物。

Fromont et al (2020) Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 63 6784 PMID: 32433887

If you know of a relevant reference for CS 640, please let us know.

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关键词: CS 640, CS 640 supplier, CS640, calmodulin, dependent, kinase, inhibitors, inhibitor, inhibit, inhibits, CAMK, potent, insulin, obesity, glucose, CaM, Kinase, 7982, Tocris Bioscience

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