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DA ZP1

Cat. No. 7444 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorogenic Zn(II) sensor for isolation of stem cell derived β cells
化学名： 3',6'-bis(Acetyloxy)-4',5'-bis[[bis(2-pyridinylmethyl)amino]methyl]-2',7'-dichlorospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
纯度： ≥90% (HPLC)
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引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DA ZP1

DA ZP1 (diacetylated Zinpyr1) is a fluorogenic Zn(II) sensor (Kd Zn2+ = 0.6 nM). It can be used to image and isolate pancreatic β-cells and β-like cells in vitro. Used to purify live stem cell-derived β-like cells. It can image transplanted islet grafts and endogenous mouse islets in vivo. DA ZP1 is non-fluorescent in the absence of Zn(II) ions but its binding with Zn(II) promotes hydrolytic cleavage of the acetyl groups, generating a strong fluorescent signal. Excitation and emission maxima (λ) are 490 nm and 522 nm, respectively.

Optical Data for DA ZP1

λabs 490 nm
λem 522 nm
Cell Permeable Yes
Application Flow Cytometry

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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技术数据 for DA ZP1

分子量 907.81
公式 C50H40Cl2N6O7
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1816254-69-9
PubChem ID 86305621
InChI Key HPUUCJUOCSGDIK-UHFFFAOYSA-N
Smiles CC(OC1=C(C=C2C(OC3=C(C(OC(C)=O)=C(C=C3C24OC(C5=CC=CC=C45)=O)Cl)CN(CC6=CC=CC=N6)CC7=CC=CC=N7)=C1CN(CC8=CC=CC=N8)CC9=CC=CC=N9)Cl)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DA ZP1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.82 2

制备储备液 for DA ZP1

以下数据基于产品分子量 907.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.02 mM 55.08 mL 275.39 mL 550.78 mL
0.1 mM 11.02 mL 55.08 mL 110.16 mL
0.2 mM 5.51 mL 27.54 mL 55.08 mL
1 mM 1.1 mL 5.51 mL 11.02 mL

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参考文献 for DA ZP1

参考文献是支持产品生物活性的出版物。

Kahraman et al (2021) Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells. Life Sci.Alliance 4 e202000840 PMID: 33514654

Zastrow et al (2016) Reaction-based probes for imaging mobile zinc in live cells and tissues. ACS Sens. 32 32 PMID: 26878065

If you know of a relevant reference for DA ZP1, please let us know.

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关键词: DA ZP1, DA ZP1 supplier, DAZP1, DA-ZP1, fluorogenic, Zn, (II), sensor, fluorescence, fluorescent, probe, islet, β-cells, β-like, cells, indicators, sensors, ions, zinc, stem, cell-derived, beta, -like, purification, , in, vivo, Fluorescent, Cell, Indicators, and, Sensors, Ion, 7444, Tocris Bioscience

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该领域的文献

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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