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DY 268

Cat. No. 5656 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent FXR antagonist
化学名： 1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DY 268

DY 268 is a potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

许可信息

Sold under license from the Beckman Research Institute of the City of Hope.

技术数据 for DY 268

分子量 560.66
公式 C30H32N4O5S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1609564-75-1
PubChem ID 90656831
InChI Key KQSPAAPFKIEUGH-UHFFFAOYSA-N
Smiles CC1=C(S(N2CCOCC2)(=O)=O)C=C(NC(C3=CN(CC4=CC(OC)=CC=C4)N=C3C5=CC=C(C)C=C5)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DY 268

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.07 100

制备储备液 for DY 268

以下数据基于产品分子量 560.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for DY 268

参考文献是支持产品生物活性的出版物。

Yu et al (2014) Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 22 2919 PMID: 24775917

If you know of a relevant reference for DY 268, please let us know.

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关键词: DY 268, DY 268 supplier, DY268, farnesoid, X, receptors, antagonists, antagonism, FXR, nuclear, potent, LXR-like, Receptors, 5656, Tocris Bioscience

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