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Fluvastatin sodium

Cat. No. 3309 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent HMG-CoA reductase inhibitor
化学名： (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Fluvastatin sodium

Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

化合物库 for Fluvastatin sodium

Fluvastatin sodium is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Fluvastatin sodium

分子量 433.45
公式 C24H25FNNaO4
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 93957-55-2
PubChem ID 76969265
InChI Key BNZHURJBOKXWJX-ZKBIPVLYSA-L
Smiles [Na+].[Na+].CC(C)N1C(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2.CC(C)N1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Fluvastatin sodium

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 10.84 25
DMSO 43.34 100

制备储备液 for Fluvastatin sodium

以下数据基于产品分子量 433.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.54 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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产品说明书 for Fluvastatin sodium

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Fluvastatin sodium

参考文献是支持产品生物活性的出版物。

Dansette et al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by STAT. Exp.Toxicol.Pathol. 52 145 PMID: 10965989

Yamamoto et al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227 PMID: 11273020

Turner et al (2007) Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458 PMID: 18049315

If you know of a relevant reference for Fluvastatin sodium, please let us know.

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关键词: Fluvastatin sodium, Fluvastatin sodium supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Reductase, 3309, Tocris Bioscience

5 篇 Fluvastatin sodium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Fluvastatin sodium 的部分引用包括：

Li and Fountain (2012) Fluvastatin suppresses native and recombinant human P2X4 receptor function. Purinergic Signal 8 311 PMID: 22222818

Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Am J Physiol Renal Physiol 2 1176 PMID: 22202492

Bergman et al (2011) Studies on the antibacterial effects of STAT--in vitro and in vivo. PLoS One 6 e24394 PMID: 21912631

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