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G418 disulfate salt

Cat. No. 4131 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Aminoglycoside antibiotic; used in cell culture
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for G418 disulfate salt

G418 disulfate salt is an aminoglycosidic antibiotic. Inhibits protein synthesis in both prokaryotic and eukaryotic cells. Used for selection of eukaryotic cells transfected with the neo gene.

This product has been cell culture tested.

技术数据 for G418 disulfate salt

分子量 692.71
公式 C20H40N4O10.2H2SO4
储存 Store at +4°C
CAS Number 108321-42-2
PubChem ID 206347
InChI Key UHEPSJJJMTWUCP-DHDYTCSHSA-N
Smiles N[C@H]1[C@H](O[C@]2([H])[C@H](O)[C@@H](NC)[C@@](C)(O)CO2)[C@@H](O)[C@H](O[C@]3([H])[C@H](N)[C@@H](O)[C@H](O)[C@]([C@H](O)C)([H])O3)[C@@H](N)C1.OS(O)(=O)=O.OS(O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for G418 disulfate salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 51.95 75

制备储备液 for G418 disulfate salt

以下数据基于产品分子量 692.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 1.92 mL 9.62 mL 19.25 mL
3.75 mM 0.38 mL 1.92 mL 3.85 mL
7.5 mM 0.19 mL 0.96 mL 1.92 mL
37.5 mM 0.04 mL 0.19 mL 0.38 mL

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产品说明书 for G418 disulfate salt

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化学品安全技术说明书

参考文献 for G418 disulfate salt

参考文献是支持产品生物活性的出版物。

Wagman et al (1974) Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation and preliminary characterization. Antimicrob.Agents Chemother. 6 144 PMID: 15828184

Bar-Nun et al (1983) G-418, an elongation inhibitor of 80 S ribosomes. Biochim.Biophys.Acta. 741 123 PMID: 6193810

Burke and Mogg (1985) Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromo. Nucleic Acids Res. 13 6265 PMID: 2995924

If you know of a relevant reference for G418 disulfate salt, please let us know.

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关键词: G418 disulfate salt, G418 disulfate salt supplier, antibiotics, neomycin, resistance, cell, culture, aminoglycoside, inhibitors, inhibits, protein, synthesis, eukaryotes, eukaryotic, prokaryotes, prokaryotic, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 4131, Tocris Bioscience

1 篇 G418 disulfate salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 G418 disulfate salt 的部分引用包括：

Yuan-Soon et al (2021) Curcumin-induced antitumor effects on triple-negative breast cancer patient-derived xenograft tumor mice through inhibiting salt-induced kinase-3 protein. J Food Drug Anal 29 622-637 PMID: 35649138

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G418 maintains stable expression of recombinant hRyR2 in HEK293 cells..
By Niroj Shrestha on 01/26/2019
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293

G418 was reconstituted in milli-Q water to get a stock solution of 50 mg/ml. The stock was diluted to 250 mcg/ml in DMEM containing 10% FBS, 4 mM glutamine, 10 mM HEPES and puromycin (5 mcg/ml) and used to culture HEK293 cell line, stably expressing hRyR2-IRES-GFP.

Stock solutions should be stored in aliquots at -20°C.

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