主页 / 药理学 / Ion Channels / Chloride Channels / CFTR / CFTR Blockers / GlyH 101

GlyH 101

Cat. No. 5485 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Reversible, voltage-dependent CFTR chloride channel blocker
化学名： N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GlyH 101

GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

技术数据 for GlyH 101

分子量 493.15
公式 C19H15Br2N3O3
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 328541-79-3
PubChem ID 11260414
InChI Key FLGYCSPPJQJZCH-LCYFTJDESA-N
Smiles O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GlyH 101

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.31 100

制备储备液 for GlyH 101

以下数据基于产品分子量 493.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.14 mL 20.28 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for GlyH 101

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GlyH 101

参考文献是支持产品生物活性的出版物。

Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125 PMID: 15277574

Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042 PMID: 22923500

If you know of a relevant reference for GlyH 101, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CFTR Blockers

关键词: GlyH 101, GlyH 101 supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, 5485, Tocris Bioscience

篇 GlyH 101 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 GlyH 101 的引用文献。 您是否知道使用了 Tocris GlyH 101 的优秀论文？ 请告知我们.

GlyH 101 的评论

目前没有该产品的评论。 Be the first to review GlyH 101 and earn rewards!

Have you used GlyH 101?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review