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GRL 0617

Cat. No. 7280 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Coronavirus PLpro inhibitor
化学名： 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GRL 0617

GRL 0617 is a coronavirus papain-like protease (Plpro) inhibitor (IC50 values are 0.6 and 0.8 μM for SARS-COV and SARS-CoV-2 PLpro, respectively). Inhibits deubiquitination activity of SARS-CoV PLpro. Displays no inhibition of human deubiquitinating enzymes. Improves cell viability following SARS-CoV infection. Inhibits SARS-CoV-2 viral replication and induces antiviral immune signaling pathways following SARS-CoV-2 infection in CaCo-2 cells.

化合物库 for GRL 0617

GRL 0617 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GRL 0617

分子量 304.39
公式 C20H20N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1093070-16-6
PubChem ID 24941262
InChI Key UVERBUNNCOKGNZ-CQSZACIVSA-N
Smiles C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(N)=C3)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GRL 0617

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.44 100
ethanol 30.44 100

制备储备液 for GRL 0617

以下数据基于产品分子量 304.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.85 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for GRL 0617

参考文献是支持产品生物活性的出版物。

Ratia et al (2008) A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.USA. 105 16119 PMID: 18852458

Freitas et al (2020) Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-Like protease. ACS Infect.Dis. 6 2099 PMID: 32428392

Shin et al (2020) Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587 657 PMID: 32726803

If you know of a relevant reference for GRL 0617, please let us know.

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关键词: GRL 0617, GRL 0617 supplier, GRL0617, coronavirus, papain, like, protease, plpro, PLpro, inhibitors, inhibits, SARS-Cov, SARS-CoV-2, antiviral, Deubiquitinating, Enzymes, Papain-like, Proteases, Coronavirus, 7280, Tocris Bioscience

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