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GSK 2033

Cat. No. 5694 7 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent LXR antagonist
化学名： 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献 (7)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2033

GSK 2033 is a potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.

化合物库 for GSK 2033

GSK 2033 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 2033

分子量 591.66
公式 C29H28F3NO5S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1221277-90-2
PubChem ID 46203250
InChI Key PSOXOVKYGWBTPB-UHFFFAOYSA-N
Smiles CC1=CC(C)=CC(C)=C1S(N(CC2=CC=C(C(F)(F)F)O2)CC(C=C3)=CC=C3C4=CC(S(C)(=O)=O)=CC=C4)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2033

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.83 20

制备储备液 for GSK 2033

以下数据基于产品分子量 591.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 8.45 mL 42.25 mL 84.51 mL
1 mM 1.69 mL 8.45 mL 16.9 mL
2 mM 0.85 mL 4.23 mL 8.45 mL
10 mM 0.17 mL 0.85 mL 1.69 mL

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参考文献 for GSK 2033

参考文献是支持产品生物活性的出版物。

Zuercher et al (2010) Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 53 3412 PMID: 20345102

Solt et al (2012) LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 7 e46615 PMID: 23029557

If you know of a relevant reference for GSK 2033, please let us know.

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关键词: GSK 2033, GSK 2033 supplier, GSK2033, Potent, LXR, antagonists, liver, x, receptors, LXR-like, Receptors, 5694, Tocris Bioscience

7 篇 GSK 2033 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 2033 的部分引用包括：

Hutchinson et al (2019) Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells. Int J Mol Sci 20 PMID: 31269628

Bruschi et al (2019) PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun 3 1191 PMID: 31497741

Amaya et al (2023) Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. Cell Mol Life Sci 80 96 PMID: 36930354

Baek et al (2021) Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene 40 2872-2883 PMID: 33742124

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