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GSK 4716

Cat. No. 3075 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective ERRγ and ERRβ agonist
别名： GW4716
化学名： 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 4716

GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.

技术数据 for GSK 4716

分子量 282.34
公式 C17H18N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 101574-65-6
PubChem ID 5331325
InChI Key IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Smiles OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 4716

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.23 100
ethanol 28.23 100

制备储备液 for GSK 4716

以下数据基于产品分子量 282.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for GSK 4716

参考文献是支持产品生物活性的出版物。

Zuercher et al (2005) Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 48 3107 PMID: 15857113

Ariazi and Jordan (2006) Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 6 203 PMID: 16515477

Wang et al (2006) X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 281 37773 PMID: 16990259

If you know of a relevant reference for GSK 4716, please let us know.

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关键词: GSK 4716, GSK 4716 supplier, Selective, ERRγ, ERRgamma, ERRβ, ERRbeta, agonists, Estrogen, related, Receptors, GSK4716, GW4716, and, Related, 3075, Tocris Bioscience

1 篇 GSK 4716 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 4716 的部分引用包括：

Weber et al (2014) Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78 50 PMID: 25424546

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Pathways for GSK 4716

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.