GW 1929 hydrochloride

Cat. No. 1664 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective PPARγ agonist. Orally active

化学名： N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GW 1929 hydrochloride

GW 1929 hydrochloride is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC₅₀ values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

技术数据 for GW 1929 hydrochloride

分子量	532.03
公式	C₃₀H₂₉N₃O₄.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	1217466-21-1
PubChem ID	76453663
InChI Key	KXNKIKXTGRMLEY-UHFFFAOYSA-N
Smiles	Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 1929 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	49.56	100 温和加热
	water	26.6	50

制备储备液 for GW 1929 hydrochloride

以下数据基于产品分子量 532.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.4 mL	18.8 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for GW 1929 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GW 1929 hydrochloride

参考文献是支持产品生物活性的出版物。

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID: 10389847

Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729 PMID: 11579205

Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651 PMID: 11373275

If you know of a relevant reference for GW 1929 hydrochloride, please let us know.

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关键词: GW 1929 hydrochloride, GW 1929 hydrochloride supplier, Selective, PPARγ, PPARgamma, agonists, orally, active, Peroxisome, Proliferator-activating, Receptors, PPAR, GW1929, hydrochloride, GlaxoSmithKline, GSK, 1664, Tocris Bioscience

2 篇 GW 1929 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GW 1929 hydrochloride 的部分引用包括：

Hatano et al (2010) Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators. Endocrinology 125 160 PMID: 19818482

Chai et al (2013) Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS One 8 e62934 PMID: 23658787

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