L-368,899 hydrochloride

Name: L-368,899 hydrochloride
Brand: Tocris Bioscience
SKU: 2641
Rating: 5 (1 reviews)

Cat. No. 2641 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, non-peptide oxytocin receptor antagonist

化学名： (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-368,899 hydrochloride

L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC₅₀ = 8.9 nM) that displays > 40-fold selectivity over vasopressin V_1a and V₂ receptors (IC₅₀ values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.

化合物库 for L-368,899 hydrochloride

L-368,899 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-368,899 hydrochloride

分子量	627.68
公式	C₂₆H₄₂N₄O₅S₂.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
PubChem ID	90488775
InChI Key	WJPIJZWOCNBGTR-HILSUTFGSA-N
Smiles	CC(C=CC=C1)=C1N2CCN(S(C[C@@]34CC[C@@H](C4(C)C)C[C@@H]3NC([C@@H](N)CCS(C)(=O)=O)=O)(=O)=O)CC2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-368,899 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	59.12	100
	DMSO	59.12	100

制备储备液 for L-368,899 hydrochloride

以下数据基于产品分子量 627.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.97 mL	15.93 mL
5 mM	0.32 mL	1.59 mL	3.19 mL
10 mM	0.16 mL	0.8 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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产品说明书 for L-368,899 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-368,899 hydrochloride

参考文献是支持产品生物活性的出版物。

Williams et al (1994) 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): an orally bioavailable, non-peptide oxyt. antagonist with potential util J.Med.Chem. 37 565 PMID: 8126695

Mann et al (2003) Attenuation of PGE_2α release in ewes infused with the oxyt. antagonist L-368,899. Domest.Anim.Endocrinol. 25 255 PMID: 14550509

Quattropani et al (2005) Discovery and development of a new class of potent, selective, orally active oxyt. receptor antagonist. J.Med.Chem. 48 7882 PMID: 16302826

Borthwick (2010) Oral oxyt. antagonists. J.Med.Chem. 53 6525 PMID: 20550119

If you know of a relevant reference for L-368,899 hydrochloride, please let us know.

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关键词: L-368,899 hydrochloride, L-368,899 hydrochloride supplier, Potent, non-peptide, oxytocin, receptor, antagonists, OT, Receptors, L368899, 160312-62-9, Oxytocin, 2641, Tocris Bioscience

4 篇 L-368,899 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-368,899 hydrochloride 的部分引用包括：

Gaetani et al (2010) The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxyt. Nat Commun 30 8096 PMID: 20554860

Pont et al (2012) Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol.Endocrinol. 26 1743 PMID: 22902539

Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731

Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546

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