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Submit ReviewLG 100268
说明： Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
化学名： 6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for LG 100268
LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.
化合物库 for LG 100268
LG 100268 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LG 100268
| 分子量 | 363.49 |
| 公式 | C24H29NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 153559-76-3 |
| PubChem ID | 3922 |
| InChI Key | SLXTWXQUEZSSTJ-UHFFFAOYSA-N |
| Smiles | CC1=C(C2(C3=CC=C(C(O)=O)C=N3)CC2)C=C4C(C(C)(CCC4(C)C)C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LG 100268
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 18.17 | 50 |
制备储备液 for LG 100268
以下数据基于产品分子量 363.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.5 mL | 27.51 mL | 55.02 mL |
| 2.5 mM | 1.1 mL | 5.5 mL | 11 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.1 mL |
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产品说明书 for LG 100268
参考文献 for LG 100268
参考文献是支持产品生物活性的出版物。
Lala et al (1996) Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 383 450 PMID: 8837780
Boehm et al (1995) Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 38 3146 PMID: 7636877
If you know of a relevant reference for LG 100268, please let us know.
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关键词: LG 100268, LG 100268 supplier, LG100268, Retiniod, X, receptor, RXR, agonists, activators, activates, potent, selective, Retinoid, Receptor, PPARgamma, Receptors, 5920, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.