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Lonidamine

Cat. No. 1646 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Mitochondrial hexokinase inhibitor
别名： AF 1890
化学名： 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lonidamine

Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

化合物库 for Lonidamine

Lonidamine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Lonidamine

分子量 321.16
公式 C15H10Cl2N2O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 50264-69-2
PubChem ID 39562
InChI Key WDRYRZXSPDWGEB-UHFFFAOYSA-N
Smiles OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lonidamine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 1.61 5
DMSO 32.12 100

制备储备液 for Lonidamine

以下数据基于产品分子量 321.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.14 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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产品说明书 for Lonidamine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Lonidamine

参考文献是支持产品生物活性的出版物。

De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891

Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425

Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318

Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093

If you know of a relevant reference for Lonidamine, please let us know.

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关键词: Lonidamine, Lonidamine supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, AF, 1890, Hexokinases, 1646, Tocris Bioscience

1 篇 Lonidamine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lonidamine 的部分引用包括：

Panina et al (2019) A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs. Cell Death Dis 10 617 PMID: 31409768

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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