Megestrol Acetate

Cat. No. 6285 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Synthetic progesterone analog

化学名： 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Megestrol Acetate

Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC₅₀ = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

化合物库 for Megestrol Acetate

Megestrol Acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Megestrol Acetate

分子量	384.51
公式	C₂₄H₃₂O₄
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	595-33-5
PubChem ID	11683
InChI Key	RQZAXGRLVPAYTJ-GQFGMJRRSA-N
Smiles	[H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Megestrol Acetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	19.23	50
	ethanol	7.69	20

制备储备液 for Megestrol Acetate

以下数据基于产品分子量 384.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.2 mL	26.01 mL	52.01 mL
2.5 mM	1.04 mL	5.2 mL	10.4 mL
5 mM	0.52 mL	2.6 mL	5.2 mL
25 mM	0.1 mL	0.52 mL	1.04 mL

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产品说明书 for Megestrol Acetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Megestrol Acetate

参考文献是支持产品生物活性的出版物。

Zhang and Chow (2004) The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426

Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926

If you know of a relevant reference for Megestrol Acetate, please let us know.

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关键词: Megestrol Acetate, Megestrol Acetate supplier, Megestrol, acetate, progesterone, analog, agonists, agonism, weight, gain, tumor, cancer, Progesterone, Receptor, 6285, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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