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ML 351

Cat. No. 6448 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective 12/15 LOX inhibitor; active in vivo
化学名： 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 351

ML 351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.

化合物库 for ML 351

ML 351 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 351

分子量 249.27
公式 C15H11N3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 847163-28-4
PubChem ID 664510
InChI Key DYXYXTDIFMDJIR-UHFFFAOYSA-N
Smiles CNC1=C(C#N)N=C(C2=CC=CC3=C2C=CC=C3)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 351

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.93 100

制备储备液 for ML 351

以下数据基于产品分子量 249.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.06 mL 40.12 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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参考文献 for ML 351

参考文献是支持产品生物活性的出版物。

Rai et al (2014) Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 57 4035 PMID: 24684213

Rai et al (2014) Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program PMID: 24672829

If you know of a relevant reference for ML 351, please let us know.

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关键词: ML 351, ML 351 supplier, ML351, Selective, 12/15-lipoxygenase, inhibitors, inhibits, 12/15, LOX, Lipoxygenase, 6448, Tocris Bioscience

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