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Molnupiravir

Cat. No. 7586 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection
化学名： β-D-N4-hydroxycytidine-5'-isopropyl ester
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Molnupiravir

Molnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). Molnupiravir competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, Molnupiravir improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.

技术数据 for Molnupiravir

分子量 329.31
公式 C13H19N3O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2492423-29-5
PubChem ID 145996610
InChI Key HTNPEHXGEKVIHG-QCNRFFRDSA-N
Smiles CC(C(OC[C@H]1O[C@@H](N2C=CC(NO)=NC2=O)[C@@H]([C@@H]1O)O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Molnupiravir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.93 100
water 32.93 100

制备储备液 for Molnupiravir

以下数据基于产品分子量 329.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.18 mL 30.37 mL
5 mM 0.61 mL 3.04 mL 6.07 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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参考文献 for Molnupiravir

参考文献是支持产品生物活性的出版物。

Toots et al (2019) Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci.Transl.Med. 11 eaax5866 PMID: 31645453

Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 eabb5883 PMID: 32253226

Gordon et al (2021) Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. J.Biol.Chem. 297 100770 PMID: 33989635

If you know of a relevant reference for Molnupiravir, please let us know.

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关键词: Molnupiravir, Molnupiravir supplier, broad-spectrum, antiviral, prodrug, nucleoside, analogue, analog, SARS-CoV-2, SARS-CoV, MERS-CoV, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, Coronavirus, Polymerase, 7586, Tocris Bioscience

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