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Submit ReviewNS 3623
说明： KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
化学名： N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
纯度： ≥99% (HPLC)
生物活性 for NS 3623
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.
化合物库 for NS 3623
NS 3623 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NS 3623
| 分子量 | 427.18 |
| 公式 | C15H10BrF3N6O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 343630-41-1 |
| PubChem ID | 9954236 |
| InChI Key | JXPULDIATMTIIN-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NS 3623
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 42.72 | 100 |
制备储备液 for NS 3623
以下数据基于产品分子量 427.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.7 mL | 23.41 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for NS 3623
参考文献 for NS 3623
参考文献是支持产品生物活性的出版物。
Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319 PMID: 16825484
George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107 PMID: 19121809
Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996 PMID: 17325228
Calloe et al (2016) A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem.Pharmacol. 108 36 PMID: 27002181
If you know of a relevant reference for NS 3623, please let us know.
关键词: NS 3623, NS 3623 supplier, hERG, activators, cardiac, ether-a-go-go, IKr, Kv11.1, potassium, channels, voltage-gated, Kv, anti-arrhythmic, NS3623, Kv4.3, Ito, Voltage-Gated, Potassium, Channels, 4462, Tocris Bioscience
NS 3623 的评论
平均评分: 5 (Based on 1 Review.)
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Product performs well as a channel opener in experimental conditions.
By
Sadequl Islam on 10/12/2018
分析类型： In Vitro
种属： Human
Product worked amazing on experimental conditions. Shows channel opening properties and must be dissolved in Tween 20–propylene glycol mixture.NS3623 affects the voltage-dependent potassium channel opening.
