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Submit ReviewOxaliplatin
说明： DNA cross-linking antitumor agent
别名： Eloxatin
化学名： Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
纯度： ≥99% (HPLC)
生物活性 for Oxaliplatin
Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.
技术数据 for Oxaliplatin
| 分子量 | 397.29 |
| 公式 | C8H14N2O4Pt |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 61825-94-3 |
| PubChem ID | 9887054 |
| InChI Key | ZROHGHOFXNOHSO-BNTLRKBRSA-L |
| Smiles | [Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Oxaliplatin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.99 | 5 温和加热 |
制备储备液 for Oxaliplatin
以下数据基于产品分子量 397.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 50.34 mL | 251.71 mL | 503.41 mL |
| 0.25 mM | 10.07 mL | 50.34 mL | 100.68 mL |
| 0.5 mM | 5.03 mL | 25.17 mL | 50.34 mL |
| 2.5 mM | 1.01 mL | 5.03 mL | 10.07 mL |
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产品说明书 for Oxaliplatin
参考文献 for Oxaliplatin
参考文献是支持产品生物活性的出版物。
Culy et al (2000) Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 60 895 PMID: 11085200
Raymond et al (2002) Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther. 1 227 PMID: 12467217
Mani et al (2002) Oxaliplatin: a review of evolving concepts. Cancer Invest. 20 246 PMID: 11901545
If you know of a relevant reference for Oxaliplatin, please let us know.
关键词: Oxaliplatin, Oxaliplatin supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducers, platinum-DNA, adducts, chemotherapeutics, Eloxatin, DNA,, RNA, and, Protein, Synthesis, 2623, Tocris Bioscience
7 篇 Oxaliplatin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Oxaliplatin 的部分引用包括：
Li et al (2015) FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. BMC Cancer 6 9240 PMID: 25860929
Rawlinson (2014) γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. BMC Cancer 14 483 PMID: 24996846
Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638
Fukushima et al (2015) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci 106 1000 PMID: 26017781
Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Exp Neurol 14 570 PMID: 25104095
Boyette-Davis and Dougherty (2011) Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by MinCyc. Oncotarget 229 353 PMID: 21385581
Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970
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Oxaliplatin 的评论
平均评分: 5 (基于 2 条评论。)
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Oxaliplatin induced immunogenic cell death in HCT116 cells.
By
Tahmineh Safaie on 02/28/2020
分析类型： In Vitro
种属： Human
细胞系/组织： HCT116
HCT116 cells were treated with 600 uM of Oxaliplatin for 4 hours and up regulation of surface expression of calreticulin was measured.
Oxaliplatin effectively kills melanoma cell growth in vitro.
By
Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human
Oxaliplatin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Oxaliplatin
