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Pyridostatin pentahydrochloride

Cat. No. 4763 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
化学名： 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pyridostatin pentahydrochloride

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

技术数据 for Pyridostatin pentahydrochloride

分子量 778.94
公式 C31H32N8O5.5HCl
储存 Desiccate at RT
纯度 ≥95% (HPLC)
CAS Number 1781882-65-2
PubChem ID 78243739
InChI Key SRIZPFGTXSQRFM-UHFFFAOYSA-N
Smiles NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pyridostatin pentahydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 15.58 20

制备储备液 for Pyridostatin pentahydrochloride

以下数据基于产品分子量 778.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 6.42 mL 32.09 mL 64.19 mL
1 mM 1.28 mL 6.42 mL 12.84 mL
2 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.13 mL 0.64 mL 1.28 mL

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产品说明书 for Pyridostatin pentahydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Pyridostatin pentahydrochloride

参考文献是支持产品生物活性的出版物。

Rodriguez et al (20112) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 8 301 PMID: 22306580

Müller et al (2010) Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2 1095 PMID: 21107376

Koirala et al (2011) A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 3 782 PMID: 21941250

If you know of a relevant reference for Pyridostatin pentahydrochloride, please let us know.

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关键词: Pyridostatin pentahydrochloride, Pyridostatin pentahydrochloride supplier, Pyridostatin, 5HCl, stabilizes, G-quadruplexes, DNA, damage, cell, cycle, arrest, proto-oncogene, SRC, telomerase, telomeric, DNA-dependent, protein, kinase, catalytic, DNA-PKcs, sunbunit, Cell, Cycle, Inhibitors, Checkpoint, Control, Kinases, Src, 4763, Tocris Bioscience

1 篇 Pyridostatin pentahydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pyridostatin pentahydrochloride 的部分引用包括：

Sven et al (2021) Inosine Substitutions in RNA Activate Latent G-Quadruplexes. J Am Chem Soc 143 15120-15130 PMID: 34520206

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该领域的文献

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