QWF

Cat. No. 6642 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： MRGPRX2 antagonist; also NK₁ receptor antagonist

纯度： ≥90% (HPLC)

引用文献 (2)

实验方案 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for QWF

QWF is a tripeptide substance P (SP) antagonist (IC₅₀ = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

For more information about how QWF may be used, see our protocol:

3D Culture of Lung Alveolar Cells

技术数据 for QWF

分子量	697.78
公式	C₃₈H₄₃N₅O₈
序列	QWF (Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl)
储存	Store at -20°C
纯度	≥90% (HPLC)
CAS Number	126088-82-2
PubChem ID	336446954
InChI Key	ZFZOHFAASQHWER-NCRUWMDKNA-N
Smiles	CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QWF

溶解性	Soluble to 10 mg/ml in DMSO

产品说明书 for QWF

分析证书/产品说明书

化学品安全技术说明书

参考文献 for QWF

参考文献是支持产品生物活性的出版物。

Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965

Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033

If you know of a relevant reference for QWF, please let us know.

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关键词: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience

2 篇 QWF 的引用文献

引用文献是使用了 Tocris 产品的出版物。 QWF 的部分引用包括：

Caroline L et al (2020) Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity 53 1063-1077.e7 PMID: 33098765

Song and Shim et al (2021) Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice Biomol Ther (Seoul) 30(1) 38 PMID: 34263729

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QWF 实验方案

以下实验方案包含使用 QWF（目录编号 6642）的更多信息。

3D Culture of Lung Alveolar Cells

QWF