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Remdesivir

Cat. No. 7226 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
别名： GS-5734
化学名： 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Remdesivir

Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.

化合物库 for Remdesivir

Remdesivir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Remdesivir

分子量 602.58
公式 C27H35N6O8P
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1809249-37-3
PubChem ID 121304016
InChI Key RWWYLEGWBNMMLJ-YSOARWBDSA-N
Smiles CCC(COC([C@@H](N[P@](OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N)(OC4=CC=CC=C4)=O)C)=O)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Remdesivir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 60.26 100
ethanol 12.05 20

制备储备液 for Remdesivir

以下数据基于产品分子量 602.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.3 mL 16.6 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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产品说明书 for Remdesivir

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Remdesivir

参考文献是支持产品生物活性的出版物。

Sheahan et al (2020) Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 11 222 PMID: 31924756

Warren et al (2016) Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531 381 PMID: 26934220

Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 178 104786 PMID: 32251767

If you know of a relevant reference for Remdesivir, please let us know.

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关键词: Remdesivir, Remdesivir supplier, antivirals, RNA-dependent, RNA, polymerase, inhibits, inhibitors, RdRp, SARS-CoV-2, MERS, severe, acute, respiratory, syndrome, middle, eastern, ebola, virus, EBOV, coronaviruses, Covid-19, broad, spectrum, Veklury, GS-5734, Polymerase, COVID-19, Coronavirus, Non-selective, Antivirals, 7226, Tocris Bioscience

2 篇 Remdesivir 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Remdesivir 的部分引用包括：

Allison B et al (2022) Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line. Front Cell Neurosci 16 941031 PMID: 36090793

Marc et al (2023) A proteome-scale map of the SARS-CoV-2-human contactome. Nat Biotechnol 41 140-149 PMID: 36217029

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