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SID 26681509

Cat. No. 3625 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cathepsin L inhibitor
化学名： N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SID 26681509

SID 26681509 is a potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

化合物库 for SID 26681509

SID 26681509 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SID 26681509

分子量 539.65
公式 C27H33N5O5S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 958772-66-2
PubChem ID 16725315
InChI Key OTIWAYTTYNFEKL-QFIPXVFZSA-N
Smiles O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SID 26681509

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.98 50
ethanol 5.4 10

制备储备液 for SID 26681509

以下数据基于产品分子量 539.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.71 mL 18.53 mL 37.06 mL
2.5 mM 0.74 mL 3.71 mL 7.41 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
25 mM 0.07 mL 0.37 mL 0.74 mL

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Reconstitution Calculator

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产品说明书 for SID 26681509

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SID 26681509

参考文献是支持产品生物活性的出版物。

Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34 PMID: 18403718

Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210 PMID: 18060772

If you know of a relevant reference for SID 26681509, please let us know.

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关键词: SID 26681509, SID 26681509 supplier, SID26681509, cathepsin, L, inhibitors, inhibits, cysteine, protease, antimalarial, Cathepsin, Calcium-Sensitive, Proteases, 3625, Tocris Bioscience

1 篇 SID 26681509 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SID 26681509 的部分引用包括：

Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839

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SID 26681509 的评论

平均评分: 5 (Based on 1 Review.)

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test.
By Dongzheng Gai on 10/04/2021
分析类型： In Vitro
种属： Mouse
细胞系/组织： Primary macrophage

The cathepsin L inhibitor SID 26681509 works excellent in suppressing the cell lysate cathepsin L activity.

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