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SJ 10542

Cat. No. 7727 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective JAK2/3 Degrader (PROTAC®)
化学名： 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
纯度： ≥97% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SJ 10542

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC®) (DC50 values are 11 nM and 14 nM; Dmax = 92% and 90% for JAK3 and JAK2, respectively); uses a phenyl glutarimide ligand as the cereblon recruiter. Degrades JAK2 in ex vivo cell lines and patient derived xenografts (DC50= <120 nM) and displays high selectivity over GSPT1 and other members of the JAK family.

JAK3 antibody validated for Western Blot also available: Catalog # MAB4699.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from St. Jude Children's Research Hospital

技术数据 for SJ 10542

分子量 818.96
公式 C41H46N12O5S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 2789678-92-6
PubChem ID 162679331
InChI Key WBEBZVDAHMXWJN-UHFFFAOYSA-N
Smiles O=C(NC1=O)CCC1C2=CC=C(N3CCN(CCCNC(C4=CC=C(NC5=NC6=C(C=CN6)C(C7=CN(C8(CC#N)CN(S(CC)(=O)=O)C8)N=C7)=N5)C=C4)=O)CC3)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SJ 10542

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.95 50

制备储备液 for SJ 10542

以下数据基于产品分子量 818.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.44 mL 12.21 mL 24.42 mL
2.5 mM 0.49 mL 2.44 mL 4.88 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
25 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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参考文献 for SJ 10542

参考文献是支持产品生物活性的出版物。

Alcock et al (2022) Development of potent and selective Janus Kinase 2/3 directing PG-PROTACs. ACS Med.Chem.Lett. 13 475 PMID: 35300081

If you know of a relevant reference for SJ 10542, please let us know.

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关键词: SJ 10542, SJ 10542 supplier, SJ10542, protacs, active, degraders, selective, JAK3, JAK2, kinases, degrades, proteolysis, targeting, chimeras, PROTAC, PROTACS, targeted, protein, degradation, tpd, baricitinib, JAK, Kinase, Degraders, 7727, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia