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SR 9243

Cat. No. 6138 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective LXR inverse agonist
化学名： N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 9243

SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

技术数据 for SR 9243

分子量 626.62
公式 C31H32BrNO4S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1613028-81-1
PubChem ID 76073169
InChI Key FYQFEJFTCLKXTQ-UHFFFAOYSA-N
Smiles CC1=CC(C)=CC(C)=C1S(N(CCC2=CC=CC(Br)=C2)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 9243

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 12.53 20

制备储备液 for SR 9243

以下数据基于产品分子量 626.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 7.98 mL 39.9 mL 79.79 mL
1 mM 1.6 mL 7.98 mL 15.96 mL
2 mM 0.8 mL 3.99 mL 7.98 mL
10 mM 0.16 mL 0.8 mL 1.6 mL

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参考文献 for SR 9243

参考文献是支持产品生物活性的出版物。

Flaveny et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 28 42 PMID: 26120082

If you know of a relevant reference for SR 9243, please let us know.

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关键词: SR 9243, SR 9243 supplier, SR9243, selective, LXR, inverse, agonists, agonism, lipogenesis, Warburg, effect, LXR-like, Receptors, 6138, Tocris Bioscience

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