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Submit ReviewTFRGAP-NH2
说明： PAR3 peptide agonist
纯度： ≥95% (HPLC)
生物活性 for TFRGAP-NH2
TFRGAP-NH2 is a protease-activated receptor 3 (PAR3) peptide agonist. In vitro, it increases the expression of heme oxygenase (HO)-1 in osteoarthritis synovial fibroblasts (OASFs).
技术数据 for TFRGAP-NH2
| 分子量 | 646.75 |
| 公式 | C29H46N10O7 |
| 序列 |
TFRGAP (Modification: Pro-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1872435-09-0 |
| PubChem ID | 162678814 |
| InChI Key | SZHZUHWALRYMHX-WZZXNIEWSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N2[C@@H](CCC2)C(N)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TFRGAP-NH2
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for TFRGAP-NH2
参考文献 for TFRGAP-NH2
参考文献是支持产品生物活性的出版物。
Subramaniam et al (2021) A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 5 2760 PMID: 34242391
Yu et al (2021) Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell Death Discov. 7 343 PMID: 34753916
Iyer et al (2021) PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Front Physiol. 12 615428 PMID: 33776786
Mogami et al (2014) Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J.Biol.Chem. 289 13295 PMID: 24652285
Lin et al (2006) c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. J.Immunol. 177 3427 PMID: 16920985
Liu et al (2012) Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways. Arthritis Res.Ther. 14 R91 PMID: 22541814
If you know of a relevant reference for TFRGAP-NH2, please let us know.
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关键词: TFRGAP-NH2, TFRGAP-NH2 supplier, TFRGAPNH2, PAR3, activating, peptides, PAR, Receptors, Proteases, Activated, proteinases, activated, Protease-Activated, 7742, Tocris Bioscience
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