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Upadacitinib

Cat. No. 7783 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： JAK1-selective inhibitor
化学名： (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Upadacitinib

Upadacitinib is a potent and selective JAK1 inhibitor (IC50 = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC50 values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

技术数据 for Upadacitinib

分子量 380.37
公式 C17H19F3N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1310726-60-3
PubChem ID 58557659
InChI Key WYQFJHHDOKWSHR-MNOVXSKESA-N
Smiles C(C)[C@H]1[C@@](C=2N3C4=C(N=CC3=NC2)NC=C4)(CN(C(NCC(F)(F)F)=O)C1)[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Upadacitinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.04 100
ethanol 19.02 50

制备储备液 for Upadacitinib

以下数据基于产品分子量 380.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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产品说明书 for Upadacitinib

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Upadacitinib

参考文献是支持产品生物活性的出版物。

Parmentier et al (2018) In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2 23 PMID: 30886973

If you know of a relevant reference for Upadacitinib, please let us know.

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关键词: Upadacitinib, Upadacitinib supplier, Potent, selective, JAK1, JAK2, JAK3, inhibitors, inhibits, janus, kinase, arthritis, in, vivo, JAK, 7783, Tocris Bioscience

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Pathways for Upadacitinib

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.