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Submit ReviewXaliproden hydrochloride
说明： High affinity 5-HT1A agonist; orally active
别名： SR 57746A
化学名： 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Xaliproden hydrochloride
Xaliproden hydrochloride is an orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..
技术数据 for Xaliproden hydrochloride
| 分子量 | 417.9 |
| 公式 | C24H22F3N.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 90494-79-4 |
| PubChem ID | 128918 |
| InChI Key | WVHBEIJGAINUBW-UHFFFAOYSA-N |
| Smiles | Cl.FC(F)(F)C1=CC(=CC=C1)C1=CCN(CCC2=CC=C3C=CC=CC3=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Xaliproden hydrochloride
参考文献 for Xaliproden hydrochloride
参考文献是支持产品生物活性的出版物。
Fournier et al (1993) Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience 55 629 PMID: 8413926
Duong et al (1999) Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons. Br.J.Pharmacol. 128 1385 PMID: 10602316
Bachy et al (1993) Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist. Fund.Clin.Pharmacol. 7 487
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关键词: Xaliproden hydrochloride, Xaliproden hydrochloride supplier, Orally, active, high, affinity, 5-HT1A, agonists, Serotonin, Receptors, SR57746A, SR, 57746A, 2491, Tocris Bioscience
1 篇 Xaliproden hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Xaliproden hydrochloride 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.