Voltage-gated Potassium (KV) Channels
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The α-subunits contain a single pore-forming region and combine to form tetramers.
Voltage-gated Potassium (KV) Channel Modulators |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 4949 | MaxiPost |
| Potassium channel modulator; exerts subtype-specific effects | |
Voltage-gated Potassium (KV) Channel Inhibitors |
|
| Cat. No. | Product Name / Activity |
| 4687 | ML 252 |
| Potent and selective KV7.2 inhibitor; brain penetrant | |
| 7486 | Roxadustat |
| Inhibitor of peak and late components of delayed rectifier potassium currents | |
Voltage-gated Potassium (KV) Channel Activators |
|
| Cat. No. | Product Name / Activity |
| 2867 | Flupirtine maleate |
| KV7 channel activator; also GABAA modulator and indirect NMDA antagonist | |
| 4305 | ICA 069673 |
| KV7.2/KV7.3 channel opener | |
| 4950 | ICA 110381 |
| KV7.2/7.3 activator; displays anticonvulsant properties | |
| 4519 | ML 213 |
| KV7.2 and KV7.4 channel opener | |
| 4777 | ML 277 |
| Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current | |
| 3062 | NS 1643 |
| KV11.1 (hERG) channel activator; antiarrhythmic | |
| 4462 | NS 3623 |
| KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic | |
| 4166 | NS 5806 |
| KV4.3 channel activator | |
| 5083 | QO 58 |
| Kv7 channel opener | |
| 6233 | Retigabine |
| KV7 channel activator | |
Voltage-gated Potassium (KV) Channel Blockers |
|
| Cat. No. | Product Name / Activity |
| 0940 | 4-Aminopyridine |
| Non-selective KV channel blocker | |
| 3489 | Astemizole |
| Potent KV11.1 (hERG) channel blocker. Also histamine H1 antagonist | |
| 6318 | Azimilide dihydrochloride |
| Kv11.1 (hERG) channel blocker | |
| 2787 | BAPTA AM |
| hKV11.1 (hERG), hKV1.3 and hKV1.5 channel blocker. Also Ca2+ chelator | |
| 1412 | Chromanol 293B |
| IKs blocker. Also blocks ICFTR | |
| 1475 | (-)-[3R,4S]-Chromanol 293B |
| IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412) | |
| 3757 | Dofetilide |
| KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | |
| 2533 | DPO-1 |
| Blocker of KV1.5 channel and IKur current | |
| 1808 | E-4031 dihydrochloride |
| KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | |
| 5676 | Guangxitoxin 1E |
| Potent Kv2.1 and Kv2.2 channel blocker | |
| 5011 | HMR 1556 |
| Potent and selective Iks channel blocker | |
| 3899 | JNJ 303 |
| Potent and selective IKs blocker | |
| 4130 | KN 92 |
| K+ channel (Kv) blocker. Inactive analog of KN 93 | |
| 1278 | KN 93 |
| K+ channel blocker (KV); also inhibitor of CaM Kinase II | |
| 1999 | Linopirdine dihydrochloride |
| KV7 (KCNQ) channel blocker | |
| 4367 | Psora 4 |
| Potent KV1.3 channel blocker | |
| 3948 | Terfenadine |
| KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist | |
| 3068 | Tetraethylammonium chloride |
| Non-selective K+ channel blocker | |
| 3829 | UK 78282 hydrochloride |
| Blocker of KV1.3 and KV1.4 channels | |
| 2000 | XE 991 dihydrochloride |
| Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents | |
Other |
|
| Cat. No. | Product Name / Activity |
| 5462 | AAQ chloride |
| Photoswitchable Kv channel blocker | |
| 2007 | Fluticasone propionate |
| Selective glucocorticoid agonist; KV1 potentiator | |
| 6087 | Perifosine |
| Modulates Kv2.1current; also PKB/Akt inhibitor | |
| 5470 | QAQ dichloride |
| Photoswitchable Nav, Kv and Cav channel blocker | |
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming α-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
External sources of pharmacological information for Voltage-gated Potassium (KV) Channels :
Voltage-Gated Potassium Channel Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
|
KV1.1 (Shaker-related) |
Human | KCNA1 | NM_000217 | Q09470 |
| Mouse | Kcna1 | NM_010595 | P16388 | |
| Rat | Kcna1 | NM_173095 | P10499 | |
|
KV1.2 (Shaker-related) |
Human | KCNA2 | NM_004974 | P16389 |
| Mouse | Kcna2 | NM_008425 | P35561 | |
| Rat | Kcna2 | NM_012970 | P63142 | |
|
KV1.3 (Shaker-related) |
Human | KCNA3 | NM_002232 | P22001 |
| Mouse | Kcna3 | NM_008418 | P16390 | |
| Rat | Kcna3 | NM_019270 | P15384 | |
|
KV1.4 (Shaker-related) |
Human | KCNA4 | NM_002233 | P22459 |
| Mouse | Kcna4 | NM_021275 | Q61423 | |
| Rat | Kcna4 | NM_012971 | P15385 | |
|
KV1.5 (Shaker-related) |
Human | KCNA5 | NM_002234 | P22460 |
| Mouse | Kcna5 | NM_145983 | Q61762 | |
| Rat | Kcna5 | NM_012972 | P19024 | |
|
KV1.6 (Shaker-related) |
Human | KCNA6 | NM_002235 | P17658 |
| Mouse | Kcna6 | NM_013568 | Q61923 | |
| Rat | Kcna6 | CH473964 | P17659 | |
|
KV1.7 (Shaker-related) |
Human | KCNA7 | NM_031886 | Q96RP8 |
| Mouse | Kcna7 | NM_010596 | Q17ST2 | |
|
KV1.8 (Shaker-related) |
Human | KCNA10 | NM_005549 | Q16322 |
| Mouse | Kcna10 | NM_001081140 | NP_001074609 | |
| KV β1 | Human | KCNAB1 | NM_003471 | Q14722 |
| Mouse | Kcnab1 | NM_010597 | P63143 | |
| Rat | Kcnab1 | NM_017303 | P63144 | |
| KV β2 | Human | KCNAB2 | NM_172130 | Q13303 |
| Mouse | Kcnab2 | NM_010598 | P62482 | |
| Rat | Kcnab2 | NM_017304 | P62483 | |
| KV β3 | Human | KCNAB3 | NM_004732 | O43448 |
| Mouse | Kcnab3 | NM_010599 | P97382 | |
| Rat | Kcnab3 | NM_031652 | Q63494 | |
|
KV2.1 (Shab-related) |
Human | KCNB1 | NM_004975 | Q14721 |
| Mouse | Kcnb1 | NM_008420 | Q03717 | |
| Rat | Kcnb1 | NM_013186 | P15387 | |
|
KV2.2 (Shab-related) |
Human | KCNB2 | NM_004770 | Q92953 |
| Mouse | Kcnb2 | NM_001098528 | A6H8H5 | |
| Rat | Kcnb2 | NM_054000 | Q63099 | |
|
KV3.1 (Shal-related) |
Human | KCNC1 | NM_004976 | P48547 |
| Mouse | Kcnc1 | NM_008421 | P15388 | |
| Rat | Kcnc1 | NM_012856 | P25122 | |
|
KV3.2 (Shal-related) |
Human | KCNC2 | NM_153748 | Q96PR1 |
| Mouse | Kcnc2 | NM_001025581 | Q14B80 | |
| Rat | Kcnc2 | NM_139216 | P22462 | |
|
KV3.3 (Shal-related) |
Human | KCNC3 | NM_004977 | Q14003 |
| Mouse | Kcnc3 | NM_008422 | Q63959 | |
| Rat | Kcnc3 | NM_053997 | Q01956 | |
|
KV3.4 (Shal-related) |
Human | KCNC4 | NM_001039574 | Q03721 |
| Mouse | Kcnc4 | NM_145922 | Q8R1C0 | |
|
KV4.1 (Shaw-related) |
Human | KCND1 | NM_004979 | Q9NSA2 |
| Mouse | Kcnd1 | NM_008423 | Q03719 | |
| Rat | Kcnd1 | NM_001105748 | NP_001099218 | |
|
KV4.2 (Shaw-related) |
Human | KCND2 | NM_012281 | Q9NZV8 |
| Mouse | Kcnd2 | NM_019697 | Q9Z0V2 | |
| Rat | Kcnd2 | NM_031730 | Q63881 | |
|
KV4.3 (Shaw-related) |
Human | KCND3 | NM_172198 | Q9UK17 |
| Mouse | Kcnd3 | NM_001039347 | Q9Z0V1 | |
| Rat | Kcnd3 | NM_031739 | Q62897 | |
| KV5.1 | Human | KCNF1 | NM_002236 | Q9H3M0 |
| Mouse | Kcnf1 | NM_201531 | Q7TSH7 | |
| Rat | Kcnf1 | M81783 | XP_001074279 | |
| KV6.1 | Human | KCNG1 | NM_002237 | Q9UIX4 |
| Mouse | Kcng1 | NM_001081134 | NP_001074603 | |
| Rat | Kcng1 | NM_001106545 | NP_001100015 | |
| KV6.2 | Human | KCNG2 | NM_012283 | Q9UJ96 |
| Mouse | Kcng2 | AK158780 | Q3TYA3 | |
| Rat | Kcng2 | NM_001107372 | Q9QYU3 | |
| KV6.3 | Human | KCNG3 | NM_172344 | Q8TAE7 |
| Mouse | Kcng3 | NM_153512 | P59053 | |
| Rat | Kcng3 | NM_001033957 | Q8R523 | |
| KV6.4 | Human | KCNG4 | NM_172347 | Q8TDN1 |
| Mouse | Kcng4 | NM_025734 | Q80XM3 | |
| KV7.1 | Human | KCNQ1 | NM_000218 | P51787 |
| Mouse | Kcnq1 | NM_008434 | P97414 | |
| Rat | Kcnq1 | NM_032073 | Q9Z0N7 | |
| KV7.2 | Human | KCNQ2 | NM_172109 | O43526 |
| Mouse | Kcnq2 | NM_001003824 | Q9Z351 | |
| Rat | Kcnq2 | NM_133322 | O88943 | |
| KV7.3 | Human | KCNQ3 | NM_004519 | O43525 |
| Mouse | Kcnq3 | NM_152923 | Q8K3F6 | |
| Rat | Kcnq3 | NM_031597 | O88944 | |
| KV7.4 | Human | KCNQ4 | NM_004700 | P56696 |
| Mouse | Kcnq4 | NM_001081142 | Q9JK97 | |
| Rat | Kcnq4 | CH473968 | Q9JK96 | |
| KV7.5 | Human | KCNQ5 | NM_019842 | Q9NR82 |
| Mouse | Kcnq5 | NM_023872 | Q9JK45 | |
| Rat | Kcnq5l | AF525937 | Q8K3W7 | |
| KV8.1 | Human | KCNV1 | NM_014379 | Q6PIU1 |
| Mouse | Kcnv1 | NM_026200 | Q8BZN2 | |
| Rat | Kcnv1 | NM_021697 | P97557 | |
| KV9.1 | Human | KCNS1 | NM_002251 | Q96KK3 |
| Mouse | Kcns1 | NM_008435 | O35173 | |
| Rat | Kcns1 | NM_053954 | O88758 | |
| KV9.2 | Human | KCNS2 | NM_020697 | Q9ULS6 |
| Mouse | Kcns2 | NM_181317 | O35174 | |
| Rat | Kcnq4 | NM_023966 | Q9ER26 | |
| KV9.3 | Human | KCNS3 | NM_002252 | Q9BQ31 |
| Mouse | Kcns3 | NM_173417 | Q8BQZ8 | |
| Rat | Kcns3 | NM_031778 | O88759 | |
|
KV10.1 (eag1) |
Human | KCNH1 | NM_002238 | O95259 |
| Mouse | Kcnh1 | NM_010600 | Q60603 | |
| Rat | Kcnh1 | NM_031742 | Q63472 | |
|
KV10.2 (eag2) |
Human | KCNH5 | NM_139318 | Q8NCM2 |
| Mouse | Kcnh5 | NM_172805 | Q920E3 | |
| Rat | Kcnh5 | NM_133610 | Q9EPI9 | |
|
KV11.1 (herg1) |
Human | KCNH2 | NM_000238 | Q12809 |
| Mouse | Kcnh2 | NM_013569 | O35219 | |
| Rat | Kcnh2 | NM_053949 | O08962 | |
|
KV11.2 (herg2) |
Human | KCNH6 | NM_030779 | Q9H252 |
| Mouse | Kcnh6 | NM_001037712 | NP_001032801 | |
| Rat | Kcnh6 | NM_053937 | O54853 | |
|
KV11.3 (herg3) |
Human | KCNH7 | NM_033272 | Q9NS40 |
| Mouse | Kcnh7 | NM_133207 | Q9ER47 | |
| Rat | Kcnh7 | NM_131912 | O54852 | |
|
KV12.1 (elk1) |
Human | KCNH8 | NM_144633 | Q96L42 |
| Mouse | Kcnh8 | NM_001031811 | P59111 | |
| Rat | Kcnh8 | NM_145095 | Q9QWS8 | |
|
KV12.2 (elk2) |
Human | KCNH3 | NM_012284 | Q9ULD8 |
| Mouse | Kcnh2 | NM_010601 | Q9WVJ0 | |
| Rat | Kcnh3 | NM_017108 | O89047 | |
|
KV12.3 (elk3) |
Human | KCNH4 | NM_012285 | Q9UQ05 |
| Mouse | Kcnh4 | NM_001081194 | NP_001074663 | |
| Rat | Kcnh4 | NM_053630 | Q9R1T9 | |
| minK | Human | KCNE1 | NM_000219 | P15382 |
| Mouse | Kcne1 | NM_008424 | P23299 | |
| Rat | Kcne1 | NM_012973 | P15383 | /tr>|
| KChIP1 | Human | KCNIP1 | NM_014592 | Q9NZI2 |
| Mouse | Kcnip1 | NM_027398 | Q9JJ57 | |
| Rat | Kcnip1 | NM_022929 | Q8R426 | |
| KChIP2 | Human | KCNIP2 | NM_173194 | Q9HD10 |
| Mouse | Kcnip2 | NM_145703 | Q9JJ69 | |
| Rat | Kcnip2 | NM_020095 | Q9JM59 | |
| KChIP3 | Human | KCNIP3 | NM_013434 | Q9Y2W7 |
| Mouse | Kcnip3 | NM_001111331 | Q9QXT8 | |
| KChIP4 | Human | KCNIP4 | NM_025221 | Q6PIL6 |
| Mouse | Kcnip4 | NM_030265 | Q6PHZ8 | |
| Rat | Kcnip4 | NM_181365 | Q99MG9 | |
| MiRP1 | Human | KCNE2 | NM_172201 | Q9Y6J6 |
| Mouse | Kcne2 | NM_134110 | Q9D808 | |
| Rat | Kcne2 | NM_133603 | P63161 | |
| MiRP2 | Human | KCNE3 | NM_005472 | Q9Y6H6 |
| Mouse | Kcne3 | NM_020574 | Q9WTW2 | |
| Rat | Kcne3 | NM_022235 | Q9JJV7 | |
| MiRP3 | Human | KCNE4 | NM_080671 | Q8WWG9 |
| Mouse | Kcne4 | NM_021342 | Q9WTW3 | |
| Rat | Kcne4 | NM_212526 | Q71FD8 |