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Submit ReviewKN 92
Description: Inactive analog of KN 93. K+ channel (Kv) blocker
Chemical Name: 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate
Purity: ≥98% (HPLC)
Biological Activity for KN 92
KN 92 is an inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.
Active Analog also available.
Technical Data for KN 92
| M. Wt | 554.98 |
| Formula | C24H25ClN2O3S.H3PO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1135280-28-2 |
| PubChem ID | 16219540 |
| InChI Key | XRQHWVVDNMJDEQ-IPZCTEOASA-N |
| Smiles | ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KN 92
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.55 | 10 |
Preparing Stock Solutions for KN 92
The following data is based on the product molecular weight 554.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.02 mL | 90.09 mL | 180.19 mL |
| 0.5 mM | 3.6 mL | 18.02 mL | 36.04 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.02 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
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Product Datasheets for KN 92
References for KN 92
References are publications that support the biological activity of the product.
Rezazadeh et al (2005) KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898
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Keywords: KN 92, KN 92 supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, Calcium, Protein, Voltage-Gated, Potassium, Channels, 4130, Tocris Bioscience
5 Citations for KN 92
Citations are publications that use Tocris products. Selected citations for KN 92 include:
Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062
Hongwei et al (2020) Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med 12 PMID: 32641489
Weng et al (2017) An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron 94 337 PMID: 28426967
Thomas et al (2021) Amyloid-Beta Mediates Homeostatic Synaptic Plasticity. J Neurosci 41 5157-5172 PMID: 33926999
Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404 PMID: 23799098
Do you know of a great paper that uses KN 92 from Tocris? Please let us know.
Reviews for KN 92
Average Rating: 5 (Based on 1 Review.)
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KN93 but not KN92 reduces maximum upstroke velocity of cardiac action potential.
By
Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes
Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential. Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.
