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Submit ReviewKN 93 phosphate
Description: CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
Purity: ≥98% (HPLC)
Biological Activity for KN 93 phosphate
KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).
Technical Data for KN 93 phosphate
| M. Wt | 599.03 |
| Formula | C26H29ClN2O4S.H3PO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1188890-41-6 |
| PubChem ID | 16760530 |
| InChI Key | NNKJTPOXLIILMB-IPZCTEOASA-N |
| Smiles | O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KN 93 phosphate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.99 | 10 |
Preparing Stock Solutions for KN 93 phosphate
The following data is based on the product molecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.69 mL | 83.47 mL | 166.94 mL |
| 0.5 mM | 3.34 mL | 16.69 mL | 33.39 mL |
| 1 mM | 1.67 mL | 8.35 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
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Product Datasheets for KN 93 phosphate
References for KN 93 phosphate
References are publications that support the biological activity of the product.
Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996 PMID: 9864285
Sumi et al (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968 PMID: 1662507
Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898
Bruno et al (2010) Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II. Synthesis 24 4193
If you know of a relevant reference for KN 93 phosphate, please let us know.
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Keywords: KN 93 phosphate, KN 93 phosphate supplier, KN93, phosphate, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, inhibitors, inhibits, water, soluble, 5215, Tocris Bioscience
5 Citations for KN 93 phosphate
Citations are publications that use Tocris products. Selected citations for KN 93 phosphate include:
Fading et al (2017) Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor-dependent manner. Synapse 71 PMID: 28524267
Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062
Mauger et al (2016) Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron 92 1266 PMID: 28009274
Zhang et al (2018) Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nat Commun 9 4272 PMID: 30323233
Mark et al (2013) Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A 110 E1026-34 PMID: 23431153
Do you know of a great paper that uses KN 93 phosphate from Tocris? Please let us know.
Reviews for KN 93 phosphate
Average Rating: 5 (Based on 1 Review.)
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KN93 phosphate inhibits HOCl-LDL-reduced Ca2+ transient amplitude in cardiomyocytes.
By
Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes
Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM. Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude
