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Submit ReviewNS 3623
Description: KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Purity: ≥99% (HPLC)
Biological Activity for NS 3623
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.
Compound Libraries for NS 3623
NS 3623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NS 3623
| M. Wt | 427.18 |
| Formula | C15H10BrF3N6O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 343630-41-1 |
| PubChem ID | 9954236 |
| InChI Key | JXPULDIATMTIIN-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 3623
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.72 | 100 |
Preparing Stock Solutions for NS 3623
The following data is based on the product molecular weight 427.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.7 mL | 23.41 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for NS 3623
References for NS 3623
References are publications that support the biological activity of the product.
Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319 PMID: 16825484
George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107 PMID: 19121809
Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996 PMID: 17325228
Calloe et al (2016) A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem.Pharmacol. 108 36 PMID: 27002181
If you know of a relevant reference for NS 3623, please let us know.
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Keywords: NS 3623, NS 3623 supplier, hERG, activators, cardiac, ether-a-go-go, IKr, Kv11.1, potassium, channels, voltage-gated, Kv, anti-arrhythmic, NS3623, Kv4.3, Ito, Voltage-Gated, Potassium, Channels, 4462, Tocris Bioscience
Citations for NS 3623
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Reviews for NS 3623
Average Rating: 5 (Based on 1 Review.)
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Product performs well as a channel opener in experimental conditions.
By
Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Human
Product worked amazing on experimental conditions. Shows channel opening properties and must be dissolved in Tween 20–propylene glycol mixture.NS3623 affects the voltage-dependent potassium channel opening.
