Mesenchymal Stem Cells
Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. They can differentiate into cells of the mesodermal lineage, such as adipocytes, and osteocytes.
Mesenchymal Stem Cells Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 7902 | PIK 90 |
| Used in hPSCs mesendoderm differentiation, also potent PI3K inhibitor | |
Other |
|
| Cat. No. | Product Name / Activity |
| 2840 | AICAR |
| AMPK activator; promotes osteogenic differentiation of bone marrow-derived MSCs | |
| 3842 | 5-Azacytidine |
| DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes | |
| 1126 | Dexamethasone |
| Anti-inflammatory glucocorticoid; induces differentiation of human MSCs | |
| 4513 | Kartogenin |
| Potently induces chondrogenesis in MSCs | |
| 6787 | KI-7 |
| Potentiates osteoblast differentiation from MSCs; A2B receptor positive allosteric modulator | |
| 7874 | N-Acetylcysteine |
| Protects hMSCs against mitoptosis, necroptosis and apoptosis; also GSH precursor and antioxidant | |
| 4106 | Nicotinamide |
| Promotes MSC differentiation; anti-inflammatory agent | |
| 5778 | 2-Phospho-L-ascorbic acid trisodium salt |
| Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs | |
| 4551 | Purmorphamine |
| Smo receptor agonist; induces differentiation of mesenchymal progenitor cells into osteoblasts | |
| 6187 | SK 216 |
| Attenuates TGF-β-dependent epithelial-mesenchymal transition; Also PAI-1 inhibitor | |
| 1496 | SP 600125 |
| JNK inhibitor; promotes differentiation of MSCs | |
| 2293 | Zebularine |
| DNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs | |
Literature for Mesenchymal Stem Cells
Tocris offers the following scientific literature for Mesenchymal Stem Cells to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products.
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Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming.
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Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow.
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Written by Rebecca Quelch and Stefan Przyborski, this poster summarizes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and potential uses.
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