Post-translational Modifications
Post-translational modifications are chemical changes to a protein that occur after translation widening the range of functions of the final protein. Many modifications occur in the RER (rough endoplasmic reticulum). There are five types of post-translational modification.
Post-Translational Modification Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 3084 | Anacardic acid |
| Inhibits SUMOylation; also inhibits histone acetyltransferase | |
| 1744 | Bay 11-7821 |
| E2 ubiquitin (Ub) conjugating enzymes inhibitor | |
| 5646 | EML 425 |
| Reversible and non-competitive p300/CBP inhibitor | |
| 2430 | GGTI 298 |
| Geranylgeranyltransferase I (GGTase I) inhibitor | |
| 6265 | Lonafarnib |
| Potent farnesyl transferase inhibitor | |
| 4993 | NSC 624206 |
| Ubiquitin-activating enzyme (E1) inhibitor | |
| 4903 | NU 9056 |
| Inhibitor of KAT5 (Tip60) histone acetyltransferase | |
| 2978 | PYR 41 |
| Ubiquitin-activating enzyme (E1) inhibitor | |
Other |
|
| Cat. No. | Product Name / Activity |
| 7932 | Ac4GalN6yne |
| Alkyne containing monosaccharide building block; used in BOCTAG | |
| 8035 | Ac4GalNAlk |
| Metabolic chemical reporter for studying glycosylation and glycoproteins | |
| 7750 | Ac4GlcNAlk |
| Metabolic chemical reporter for studying glycosylation and glycoproteins | |
| 7479 | Ac4ManNAz |
| Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe | |
| 7553 | Ac4ManNDAz |
| Photo-crosslinking probe for studying glycoproteins and glycolipids | |
| 7751 | 1-Hex-GlcNAlk |
| Metabolic chemical reporter for studying glycosylation and glycoproteins | |
| 7234 | Nitazoxanide |
| Stabilizes peptidyl arginine deiminase 2 (PAD2); inhibits Wnt signaling; broad spectrum anti-infective | |
Post-translational modifications are chemical changes to a protein that occur after translation. They widen the range of functions of the final protein. Many of these protein modifications occur in the rough endoplasmic reticulum (RER). There are five types of post-translational modifications:
- Formation of disulfide bridges
- Proper folding
- Addition and processing of carbohydrates
- Specific proteolytic cleavage
- Assembly into multimeric proteins
Examples of specific post-translational modifications include phosphorylation, sumolyation, ubiquitination, acetylation, methylation, glycosylation, hydroxylation, oxidation and deamination (conversion of arginine to citrulline). As all proteins begin with methionine, many have this first amino acid cleaved off during post-translational modification. This process occurs predominantly in the ER, Golgi and secretory vesicles.