DNA Polymerase
DNA polymerases are enzymes that catalyze the synthesis DNA.There are at least fifteen different DNA polymerases known in eukaryotes. These enzymes have roles in DNA repair, as well as DNA replication.
DNA Polymerase Inhibitors |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 5736 | Aphidicolin |
| DNA polymerase α, δ and ε inhibitor | |
| 6234 | Entecavir |
| Potent and selective hepatitis B virus inhibitor | |
| 1489 | Mithramycin A |
| Inhibitor of DNA and RNA polymerase | |
| 7684 | Rilpivirine |
| Non-nucleoside reverse transcriptase inhibitor | |
| 3666 | Tenofovir |
| Reverse transcriptase inhibitor | |
Other |
|
| Cat. No. | 产品名称/活性 |
| 4723 | T2AA |
| PCNA inhibitor; inhibits PCNA/DNA polymerase δ interaction | |
| 3253 | Triptolide |
| Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive | |
DNA polymerases cannot initiate de novo DNA synthesis; they require a primer, formed by the enzyme primase. DNA polymerases are unidirectional and can only elongate DNA chains in a 5' to 3' direction. A unique feature of some of these enzymes is their 'proofreading' ability. DNA polymerases I, II and III have 3' to 5' exonuclease activity and they can remove incorrectly newly incorporated nucleotides. This makes the error rate during DNA replication very low, hence maintaining the integrity of the genome.
External sources of pharmacological information for DNA Polymerase :
Literature for DNA Polymerase
Tocris offers the following scientific literature for DNA Polymerase to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
RNA and DNA Polymerase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| RNA Polymerase | ||||
| POLR1A | Human | POLR1A | NM_015425 | O95602 |
| Mouse | Polr1a | NM_009088 | O35134 | |
| Rat | Polr1a | NM_031772 | O54889 | |
| POLR1B | Human | POLR1B | NM_019014 | Q9H9Y6 |
| Mouse | Polr1b | NM_009086 | P70700 | |
| Rat | Polr1b | NM_031773 | O54888 | |
| POLR1C | Human | POLR1C | NM_004875 | O15160 |
| Mouse | Polr1c | NM_009085 | P52432 | |
| Rat | Polr1c | NM_001008330 | Q5RJK9 | |
| POLR1D | Human | POLR1D | NM_015972 | Q9Y2S0 |
| Mouse | Polr1d | NM_181730 | P97304 | |
| POLR1E | Human | POLR1E | NM_022490 | Q9GZS1 |
| Mouse | Polr1e | NM_022811 | Q8K202 | |
| Rat | Polr1e | NM_001107938 | XP_233004 | |
| POLR2A | Human | POLR2A | NM_000937 | P24928 |
| Mouse | Polr2a | NM_009089 | P08775 | |
| Rat | Polr2a | XM_343922 | XP_343923 | |
| POLR2B | Human | POLR2B | NM_000938 | P30876 |
| Mouse | Polr2b | NM_153798 | Q8CFI7 | |
| Rat | Polr2b | NM_001106002 | XP_214021 | |
| POLR2C | Human | POLR2C | NM_032940 | P19387 |
| Mouse | Polr2c | NM_009090 | P97760 | |
| Rat | Polr2c | NM_001012473 | Q5EB90 | |
| POLR2D | Human | POLR2D | NM_004805 | O15514 |
| Mouse | Polr2d | NM_027101 | Q9D7M8 | |
| Rat | Polr2d | NM_001108886 | XP_344660 | |
| POLR2E | Human | POLR2E | NM_002695 | P19388 |
| Mouse | Polr2e | NM_025554 | Q80UW8 | |
| Rat | Polr2e | NM_001109614 | XP_001076333 | |
| POLR2F | Human | POLR2F | NM_021974 | P61218 |
| Mouse | Polr2f | NM_027231 | P61219 | |
| Rat | Polr2f | NM_031335 | O88828 | |
| POLR2G | Human | POLR2G | NM_002696 | P62487 |
| Mouse | Polr2g | NM_026329 | P62488 | |
| Rat | Polr2g | NM_053948 | P62489 | |
| POLR2H | Human | POLR2H | NM_006232 | P52434 |
| Mouse | Polr2h | NM_145632 | Q923G2 | |
| Rat | Polr2h | NM_001134789 | Q9Z0W2 | |
| POLR2I | Human | POL2I | NM_006233 | P36954 |
| Mouse | Polr2i | NM_027259 | P60898 | |
| Rat | Polr2i | NM_001106244 | XP_214895 | |
| POLR2J | Human | POLR2J | NM_006234 | P52435 |
| Mouse | Polr2j | NM_011293 | O08740 | |
| Rat | Polr2j | NM_001105921 | XP_213753 | |
| POLR2K | Human | POLR2K | NM_005034 | P53803 |
| Mouse | Polr2k | NM_001039368 | Q63871 | |
| Rat | Polr2k | XM_219604 | XP_219604 | |
| POLR2L | Human | POLR2L | NM_021128 | P62875 |
| Mouse | Polr2l | NM_025593 | P62876 | |
| Rat | Polr2l | NM_001143911 | Q7TPA2 | |
| POLR3A | Human | POLR3A | NM_007055 | O14802 |
| Mouse | Polr3a | NM_001081247 | NP_001074716 | |
| Rat | Polr3a | XM_341388 | Q5RK26 | |
| POLR3B | Human | POLR3B | NM_018082 | Q9NW08 |
| Mouse | Polr3b | NM_027423 | P59470 | |
| Rat | Polr3b | XM_343188 | XP_343189 | |
| POLR3C | Human | POLR3C | NM_006468 | Q9BUI4 |
| Mouse | Polr3c | NM_028925 | Q9D483 | |
| Rat | Polr3c | NM_001012081 | Q5XIL3 | |
| POLR3D | Human | POLR3D | NM_001722 | P05423 |
| Mouse | Polr3d | NM_025945 | Q91WD1 | |
| Rat | Polr3d | NM_001031653 | Q4FZS9 | |
| POLR3E | Human | POLR3E | NM_018119 | Q9NVU0 |
| Mouse | Polr3e | NM_025298 | Q9CZT4 | |
| Rat | Polr3e | NM_001108503 | XP_341920 | |
| POLR3F | Human | POLR3F | NM_006466 | Q9H1D9 |
| Mouse | Polr3f | NM_029763 | Q921X6 | |
| Rat | Polr3f | NM_001107784 | XP_230642 | |
| POLR3G | Human | POLR3G | NM_006467 | O15318 |
| Mouse | Polr3g | NM_001081176 | Q6NXY9 | |
| Rat | Polr3g | NM_001109468 | XP_001061237 | |
| POLR3H | Human | POLR3H | NM_138338 | Q9Y535 |
| Mouse | Polr3h | NM_030229 | Q9D2C6 | |
| Rat | Polr3h | NM_001127295 | XP_216998 | |
| POLR3K | Human | POLR3K | NM_016310 | Q9Y2Y1 |
| Mouse | Polr3k | NM_025901 | Q9CQZ7 | |
| Rat | Polr3k | NM_001014259 | Q5FVH1 | |
| DNA Polymerase | ||||
| POLα1 | Human | POLA1 | NM_016937 | P09884 |
| Mouse | Pola1 | NM_008892 | P33609 | |
| Rat | Pola1 | XM_242396 | O89042 | |
| POLα2 | Human | POLA2 | NM_002689 | Q14181 |
| Mouse | Pola2 | NM_008893 | P33611 | |
| Rat | Pola2 | NM_053480 | O89043 | |
| POLβ | Human | POLB | NM_002690 | P06746 |
| Mouse | Polb | NM_011130 | Q8K409 | |
| Rat | Polb | NM_017141 | P06766 | |
| POLγ | Human | POLG | NM_001126131 | P54098 |
| Mouse | Polg | NM_017462 | P54099 | |
| Rat | Polg | NM_053528 | Q9QYV8 | |
| POLγ2 | Human | POLG2 | NM_007215 | Q9UHN1 |
| Mouse | Polg2 | NM_015810 | Q9QZM2 | |
| Rat | Polg2 | NM_001107060 | XP_221047 | |
| POLδ1 | Human | POLD1 | NM_002691 | P28340 |
| Mouse | Pold1 | NM_011131 | P52431 | |
| Rat | Pold1 | NM_021662 | O54747 | |
| POLδ2 | Human | POLD2 | NM_001127218 | P49005 |
| Mouse | Pold2 | NM_008894 | O35654 | |
| Rat | Pold2 | NM_001013050 | Q6AXY4 | |
| POLδ3 | Human | POLD3 | NM_006591 | Q15054 |
| Mouse | Pold3 | NM_133692 | Q9EQ28 | |
| Rat | Pol3d | NM_001024750 | Q4V7D0 | |
| POLδ4 | Human | POLD4 | NM_021173 | Q9HCU8 |
| Mouse | Pold4 | NM_027196 | Q9CWP8 | |
| Rat | Pold4 | NM_001013195 | Q6P6U6 | |
| POLε | Human | POLE | NM_006231 | Q07864 |
| Mouse | Pole | NM_011132 | Q9WVF7 | |
| Rat | Pole | NM_001107152 | XP_222255 | |
| POLε2 | Human | POLE2 | NM_002692 | P56282 |
| Mouse | Pole2 | NM_011133 | O54956 | |
| Rat | Pole2 | XM_216727 | XP_216727 | |
| POLε3 | Human | POLE3 | NM_017443 | Q9NRF9 |
| Mouse | Pole3 | NM_021498 | Q9JKP7 | |
| Rat | Pole3 | NM_001007652 | Q642A5 | |
| POLε4 | Human | POLE4 | NM_019896 | Q9NR33 |
| Mouse | Pole4 | NM_025882 | Q9CQ36 | |
| Rat | Pole4 | NM_001108634 | XP_342711 | |
| POLζ | Human | REV3L | NM_002912 | O60673 |
| POLη | Human | POLH | NM_006502 | Q9Y253 |
| Mouse | Polh | NM_030715 | Q9JJN0 | |
| Rat | Polh | NM_001108204 | XP_236934 | |
| POLθ | Human | POLQ | NM_199420 | O75417 |
| Mouse | Polq | NM_029977 | NP_084253 | |
| Rat | Polq | NM_001105878 | XP_221423 | |
| POLι | Human | POLI | NM_007195 | Q9UNA4 |
| Mouse | Poli | NM_001136090 | Q6R3M4 | |
| Rat | Poli | NM_001106137 | XP_225844 | Human | POLK | NM_016218 | Q9UHC5 |
| Mouse | Polk | NM_012048 | Q9QUG2 | |
| Rat | Polk | NM_138516 | Q8R253 | |
| POLλ | Human | POLL | NM_013274 | Q9UGP5 |
| Mouse | Poll | NM_020032 | Q9QXE2 | |
| Rat | Poll | NM_001014168 | Q5RKI3 | |
| POLμ | Human | POLM | NM_013284 | Q9NP87 |
| Mouse | Polm | NM_017401 | Q9JIW4 | |
| Rat | Polm | NM_001011912 | Q66HH0 | |
| POLν | Human | POLN | NM_181808 | Q7Z5Q5 |
| Mouse | Polm | NM_181857 | Q7TQ07 | |
| Rat | Poln | XM_573636 | XP_573636 | |
| POLσ | Human | POLS | NM_006999 | Q5XG87 |
| Mouse | Pols | NM_198600 | Q6PB75 | |
| Rat | Pols | NM_001107333 | XP_225072 | |
Our Epigenetics review gives an overview of the development of chemical probes for epigenetic targets, and discusses their biological effects.
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