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Rilpivirine

Cat. No. 7684 Submit a Review Datasheet / COA / SDS
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Description: Non-nucleoside reverse transcriptase inhibitor
Chemical Name: 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Rilpivirine

Rilpivirine is a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It has high antiviral activity against wild-type HIV-1 and mutant viruses (EC50 values are 0.4 and 0.1-2.0 nM, respectively in a cell-based assay). This compound is orally bioavailable.

Technical Data for Rilpivirine

M. Wt 366.42
Formula C22H18N6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 500287-72-9
PubChem ID 6451164
InChI Key YIBOMRUWOWDFLG-ONEGZZNKSA-N
Smiles N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rilpivirine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.32 50

Preparing Stock Solutions for Rilpivirine

The following data is based on the product molecular weight 366.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.46 mL 27.29 mL 54.58 mL
2.5 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
25 mM 0.11 mL 0.55 mL 1.09 mL

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References for Rilpivirine

References are publications that support the biological activity of the product.

Janssen et al (2005) In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J.Med.Chem. 48 1901 PMID: 15771434

Baert et al (2009) Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment. Eur.J.Pharm.Biopharm. 72 502 PMID: 19328850

If you know of a relevant reference for Rilpivirine, please let us know.

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Keywords: Rilpivirine, Rilpivirine supplier, reverse, transcriptase, inhibitors, inhibits, diarylpyrimidine, (DAPY), potent, antivirals, HIV-1, HIV, orally, bioavailable, NNRTI, non-nucleoside, DNA, Polymerase, 7684, Tocris Bioscience

Citations for Rilpivirine

Citations are publications that use Tocris products.

Currently there are no citations for Rilpivirine. Do you know of a great paper that uses Rilpivirine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.