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Submit ReviewAAQ chloride
说明： Photoswitchable Kv channel blocker
化学名： N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
纯度： ≥98% (HPLC)
生物活性 for AAQ chloride
AAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.
许可信息
Sold under license from Photoswitch Biosciences, Inc.
技术数据 for AAQ chloride
| 分子量 | 443.97 |
| 公式 | C23H30ClN5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 91826090 |
| InChI Key | CTVKLIGDHHKPIB-UHFFFAOYSA-N |
| Smiles | O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AAQ chloride
参考文献 for AAQ chloride
参考文献是支持产品生物活性的出版物。
Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID: 18311146
Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID: 22841312
Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609
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关键词: AAQ chloride, AAQ chloride supplier, selective, photoswitchable, Kv, potassium, channels, K+, blockers, ligands, Photoswitchable, Ligands, Voltage-Gated, Potassium, Channels, 5462, Tocris Bioscience
1 篇 AAQ chloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AAQ chloride 的部分引用包括：
Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur J Pharmacol. 938 175448 PMID: 36470444
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