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说明： Noncompetitive PCAF/p300 inhibitor
化学名： 2-Hydroxy-6-pentadecylbenzoic acid
纯度： ≥97% (HPLC)
生物活性 for Anacardic acid
Anacardic acid is a noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity. Also promotes cardiomyocyte differentiation from mESCs.
技术数据 for Anacardic acid
| 分子量 | 348.52 |
| 公式 | C22H36O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 16611-84-0 |
| PubChem ID | 167551 |
| InChI Key | ADFWQBGTDJIESE-UHFFFAOYSA-N |
| Smiles | OC1=C(C(O)=O)C(CCCCCCCCCCCCCCC)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Anacardic acid
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.85 | 100 | |
| ethanol | 17.43 | 50 |
制备储备液 for Anacardic acid
以下数据基于产品分子量 348.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.35 mL | 28.69 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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产品说明书 for Anacardic acid
参考文献 for Anacardic acid
参考文献是支持产品生物活性的出版物。
Kishore et al (2008) Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 51 792 PMID: 18215015
Sung et al (2008) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the Blood 111 4880 PMID: 18349320
Cui et al (2008) Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eurkaryot.Cell 7 1200
Balasubramanyam et al (2003) Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 278 19134 PMID: 12624111
Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003
Re et al (2016) Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways. Endocrine 53 681 PMID: 26547215
If you know of a relevant reference for Anacardic acid, please let us know.
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关键词: Anacardic acid, Anacardic acid supplier, hat, histone, acetyltransferase, inhibitors, inhibits, nf-kb, nf-kappab, nf-κ, aurora, kinases, A, epigenetics, cardiomyocyte, differentiation, Aurora, Kinases, Histone, Acetyltransferases, Post-translational, Modifications, Other, Ligases, Cardiomyocyte, Stem, Cells, 3084, Tocris Bioscience
1 篇 Anacardic acid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Anacardic acid 的部分引用包括：
Bonnaud et al (2015) Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. PLoS One 89 5996 PMID: 25810554
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.