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Artesunate

Cat. No. 6827 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
化学名： 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Artesunate

Artesunate suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Aretesumate is an antimalarial (Plasmodium).

技术数据 for Artesunate

分子量 384.42
公式 C19H28O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 88495-63-0
PubChem ID 6917864
InChI Key FIHJKUPKCHIPAT-AHIGJZGOSA-N
Smiles [H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@H]([C@@H]2C)OC(CCC(O)=O)=O)(O4)[H])C)[H])C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Artesunate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.44 100
ethanol 38.44 100

制备储备液 for Artesunate

以下数据基于产品分子量 384.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for Artesunate

参考文献是支持产品生物活性的出版物。

Meshnick et al (2002) Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 32 1655 PMID: 12435450

Jeong et al (2015) Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6 33046 PMID: 26426994

Liu et al (2018) Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 41 1546 PMID: 29730819

If you know of a relevant reference for Artesunate, please let us know.

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关键词: Artesunate, Artesunate supplier, malaria, antimalarial, ROS, inhibitors, inhibits, NLRP3, inflammasome, G2/M, phase, arrest, Plasmodium, falciparum, Inflammasomes, Cell, Cycle, Inhibitors, Antimalarials, 6827, Tocris Bioscience

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