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ML T7

Cat. No. 8119 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
Chemical Name: 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML T7

ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.

Technical Data for ML T7

M. Wt 506.34
Formula C27H17Cl2NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 459789-75-4
PubChem ID 3116616
InChI Key OFJOQMMYCMPPEC-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(Cl)=C1)N2C(C(C3C2=O)C(OC43C(C5=C(C4=O)C=CC=C5)=O)C6=CC=C(C=C6)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML T7

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.63 100

Preparing Stock Solutions for ML T7

The following data is based on the product molecular weight 506.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.87 mL 19.75 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References for ML T7

References are publications that support the biological activity of the product.

Ma et al (2023) Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci.Transl.Med. 15 PMID: 37967204

If you know of a relevant reference for ML T7, please let us know.

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Keywords: ML T7, ML T7 supplier, MLT7, ML, T7, T, cell, immunoglobulin, mucin, Tim3, Tim-3, inhibitor, phosphatidylserine, CEACAM1, cytokine, lymphocytes, HCC, hepatocellular, carcinoma, NK, natural, killer, Immune, Checkpoints, 8119, Tocris Bioscience

Citations for ML T7

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