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Submit ReviewCitalopram hydrobromide
说明： Highly potent and selective 5-HT uptake inhibitor
化学名： 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
纯度： ≥99% (HPLC)
生物活性 for Citalopram hydrobromide
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.
技术数据 for Citalopram hydrobromide
| 分子量 | 405.31 |
| 公式 | C20H21FN2O.HBr |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 59729-32-7 |
| PubChem ID | 77995 |
| InChI Key | WIHMBLDNRMIGDW-UHFFFAOYSA-N |
| Smiles | Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Citalopram hydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 50 | ||
| water | 10 |
制备储备液 for Citalopram hydrobromide
以下数据基于产品分子量 405.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.93 mL | 24.67 mL | 49.34 mL |
| 2.5 mM | 0.99 mL | 4.93 mL | 9.87 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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产品说明书 for Citalopram hydrobromide
参考文献 for Citalopram hydrobromide
参考文献是支持产品生物活性的出版物。
Auerbach and Hjorth (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor cital. on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 352 597 PMID: 9053730
Mateo et al (2000) Inhibition of 5-hydroxytryptamine reuptake by the antidepressant cital. in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 39 2036 PMID: 10963747
Hyttel (1982) Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch 6 277
If you know of a relevant reference for Citalopram hydrobromide, please let us know.
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关键词: Citalopram hydrobromide, Citalopram hydrobromide supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1427, Tocris Bioscience
14 篇 Citalopram hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Citalopram hydrobromide 的部分引用包括：
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Munari et al (2015) Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Psychopharmacology (Berl) 18 pyv045 PMID: 25899065
Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Mol Ther 232 2697 PMID: 25791190
Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748
Jiménez-Sánchez et al (2014) The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression. Neuropsychopharmacology 39 2673 PMID: 24871546
Morecroft et al (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Int J Neuropsychopharmacol 85 593 PMID: 19736308
Gasull-Camôs et al (2018) Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology 139 41 PMID: 29940206
Morecroft et al (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. PLoS One 20 1516 PMID: 22525513
Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin. Cardiovasc Res 37 321 PMID: 21956448
Jury et al (2015) Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation. PLoS One 10 e0117339 PMID: 25689282
Maciag et al (2006) Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31 47 PMID: 16012532
Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse
SERT blocker citalopram (1 μΜ)
Citalopram with cued fear conditioning.
By
Anonymous on 05/23/2019
分析类型： In Vivo
种属： Mouse
given before cued fear conditioning, 10mg/kg i.p. did not significantly affect freezing behavior during recall 24 hours later
dissolved in saline easily, given 60 min before behavior
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.