5-HT Transporters
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move molecules.
5-HT Transporter Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1427 | Citalopram hydrobromide |
| Highly potent and selective 5-HT uptake inhibitor | |
| 2695 | Dexfenfluramine hydrochloride |
| 5-HT reuptake inhibitor; also stimulates 5-HT release | |
| 4798 | (S)-Duloxetine hydrochloride |
| Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake | |
| 4796 | Escitalopram oxalate |
| Selective serotonin reuptake inhibitor (SSRI) | |
| 0927 | Fluoxetine hydrochloride |
| 5-HT reuptake inhibitor | |
| 1033 | Fluvoxamine maleate |
| 5-HT reuptake inhibitor | |
| 7841 | Imipramine hydrochloride |
| Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment | |
| 1588 | Indatraline hydrochloride |
| Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake | |
| 2141 | Paroxetine maleate |
| Highly potent and selective 5-HT uptake inhibitor | |
| 2395 | Sertraline hydrochloride |
| 5-HT reuptake inhibitor | |
| 2175 | Tetrabenazine |
| Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores | |
| 2917 | Venlafaxine hydrochloride |
| 5-HT and NA reuptake inhibitor (SNRI) | |
| 6202 | Vilazodone hydrochloride |
| Potent SSRI and 5-HT1A partial agonist; antidepressant | |
Other |
|
| Cat. No. | Product Name / Activity |
| 5763 | (R)-Citalopram oxalate |
| Enantiomer of escitalopram oxalate (Cat. No. 1427) | |
| 3547 | Serotonin hydrochloride |
| Endogenous substrate | |
| 7898 | ZZL 7 |
| Inhibitor of SERT and nNOS interaction | |
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move one or more molecules per cycle.
Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini, putative phosphorylation sites acting as potential targets for PKA and PKC and regions essential for 5-HT selective affinity. There is evidence to suggest that SERTs are linked to neuroticism, sexual behavior, alcoholism, clinical depression, hypertension and obsessive-compulsive disorder.
External sources of pharmacological information for 5-HT Transporters :
Literature for 5-HT Transporters
Tocris offers the following scientific literature for 5-HT Transporters to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyRequest PDF