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Submit ReviewDexfenfluramine hydrochloride
Description: 5-HT reuptake inhibitor; also stimulates 5-HT release
Alternative Names: (+)-Fenfluramine
Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Purity: ≥95% (HPLC)
Biological Activity for Dexfenfluramine hydrochloride
Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
Technical Data for Dexfenfluramine hydrochloride
| M. Wt | 267.72 |
| Formula | C12H16F3N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 3239-45-0 |
| PubChem ID | 66264 |
| InChI Key | ZXKXJHAOUFHNAS-FVGYRXGTSA-N |
| Smiles | C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dexfenfluramine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.77 | 100 | |
| DMSO | 26.77 | 100 |
Preparing Stock Solutions for Dexfenfluramine hydrochloride
The following data is based on the product molecular weight 267.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.68 mL | 37.35 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.47 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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Product Datasheets for Dexfenfluramine hydrochloride
References for Dexfenfluramine hydrochloride
References are publications that support the biological activity of the product.
Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox. Pharmacol.Biochem.Behav. 57 851 PMID: 9259015
Higgins et al (2001) Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 133 459 PMID: 11399662
Bush et al (2006) Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice. Endocrine 29 375 PMID: 16785615
If you know of a relevant reference for Dexfenfluramine hydrochloride, please let us know.
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Keywords: Dexfenfluramine hydrochloride, Dexfenfluramine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, stimulates, release, Serotonin, 5-Hydroxytryptamine, Receptors, Transporters, SERT, Monoamine, Neurotransmitter, (+)-Fenfluramine, 5-HT-Related, 5-HT3, 2695, Tocris Bioscience
4 Citations for Dexfenfluramine hydrochloride
Citations are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:
Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150
Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740
Kiyasova et al (2011) A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci 31 2756 PMID: 21414898
Banas et al (2011) Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36 423 PMID: 20927048
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.