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Submit ReviewEntecavir
说明： Potent and selective hepatitis B virus inhibitor
别名： BMS 200475,SQ 34676
化学名： 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
纯度： ≥98% (HPLC)
生物活性 for Entecavir
Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.
化合物库 for Entecavir
Entecavir is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Entecavir
| 分子量 | 277.28 |
| 公式 | C12H15N5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 142217-69-4 |
| PubChem ID | 153941 |
| InChI Key | QDGZDCVAUDNJFG-FXQIFTODSA-N |
| Smiles | O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Entecavir
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.73 | 100 |
制备储备液 for Entecavir
以下数据基于产品分子量 277.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.21 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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产品说明书 for Entecavir
参考文献 for Entecavir
参考文献是支持产品生物活性的出版物。
Innaimo et al (1997) Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob. Agents Chemother. 41 1444 PMID: 9210663
Bisacchi et al (1997) BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro Bioorganic & Medicinal Chemistry Letters 7 127
If you know of a relevant reference for Entecavir, please let us know.
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关键词: Entecavir, Entecavir supplier, Potent, selective, hepatitis, B, virus, inhibitors, HBV, inhibits, orally, bioavailable, BMS200475, SQ34676, nucleoside, reverse, transcriptase, NRTI, BMS, 200475, SQ, 34676, DNA, Polymerase, Hepatitis, Viruses, 6234, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.